Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Wycombe | 2 | 0 | Morecambe | R Lewis |
| 14/08/2010 | Stockport | 0 | 0 | Wycombe | M Brown |
| 21/08/2010 | Wycombe | 0 | 0 | Oxford | A Taylor |
| 28/08/2010 | Northampton | 1 | 1 | Wycombe | C Boyeson |
| 04/09/2010 | Accrington | 1 | 1 | Wycombe | R Madley |
| 11/09/2010 | Wycombe | 1 | 2 | Macclesfield | P Miller |
| 18/09/2010 | Aldershot | 0 | 0 | Wycombe | D Sheldrake |
| 25/09/2010 | Wycombe | 2 | 2 | Shrewsbury | G Hegley |
| 28/09/2010 | Wycombe | 4 | 2 | Barnet | F Graham |
| 02/10/2010 | Stevenage | 0 | 2 | Wycombe | D Deadman |
| 09/10/2010 | Burton | 1 | 2 | Wycombe | M Haywood |
| 16/10/2010 | Wycombe | 1 | 2 | Chesterfield | P Tierney |
| 23/10/2010 | Rotherham | 3 | 4 | Wycombe | P Quinn |
| 30/10/2010 | Wycombe | 2 | 2 | Lincoln | C Sarginson |
| 02/11/2010 | Gillingham | 0 | 2 | Wycombe | J Linington |
| 13/11/2010 | Wycombe | 1 | 0 | Bradford | M Russell |
| 20/11/2010 | Port Vale | 2 | 1 | Wycombe | J Moss |
| 23/11/2010 | Wycombe | 1 | 3 | Torquay | G Ward |
| 11/12/2010 | Wycombe | 1 | 0 | Bury | D Coote |
| 26/12/2010 | Wycombe | 2 | 1 | Hereford | D Whitestone |
| 01/01/2011 | Cheltenham | 1 | 2 | Wycombe | G Scott |
| 03/01/2011 | Wycombe | 1 | 0 | Gillingham | P Crossley |
| 08/01/2011 | Crewe | 3 | 0 | Wycombe | S Hooper |
| 15/01/2011 | Lincoln | 1 | 2 | Wycombe | G Salisbury |
| 22/01/2011 | Wycombe | 1 | 0 | Rotherham | D Phillips |
| 01/02/2011 | Wycombe | 2 | 1 | Cheltenham | S Tanner |
| 05/02/2011 | Wycombe | 1 | 1 | Port Vale | G Sutton |
| 12/02/2011 | Bradford | 1 | 0 | Wycombe | G Eltringham |
| 15/02/2011 | Southend | 3 | 2 | Wycombe | A Woolmer |
| 19/02/2011 | Wycombe | 1 | 2 | Accrington | B Malone |
| 22/02/2011 | Wycombe | 4 | 1 | Burton | O Langford |
| 26/02/2011 | Macclesfield | 0 | 1 | Wycombe | J Adcock |
| 01/03/2011 | Chesterfield | 4 | 1 | Wycombe | S Rushton |
| 05/03/2011 | Wycombe | 2 | 2 | Aldershot | G Scott |
| 08/03/2011 | Barnet | 0 | 1 | Wycombe | D Sheldrake |
| 12/03/2011 | Wycombe | 0 | 1 | Stevenage | G Horwood |
| 19/03/2011 | Shrewsbury | 1 | 1 | Wycombe | J Linington |
| 26/03/2011 | Morecambe | 0 | 3 | Wycombe | T Kettle |
| 02/04/2011 | Wycombe | 2 | 0 | Stockport | G Ward |
| 05/04/2011 | Hereford | 0 | 0 | Wycombe | O Langford |
| 09/04/2011 | Oxford | 2 | 2 | Wycombe | D Deadman |
| 16/04/2011 | Wycombe | 2 | 2 | Northampton | P Crossley |
| 22/04/2011 | Torquay | 0 | 0 | Wycombe | D Whitestone |
| 25/04/2011 | Wycombe | 2 | 0 | Crewe | D McDermid |
| 30/04/2011 | Bury | 1 | 3 | Wycombe | P Gibbs |
| 07/05/2011 | Wycombe | 3 | 1 | Southend | N Swarbrick |