Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2009 | Charlton | 3 | 2 | Wycombe | D Deadman |
| 15/08/2009 | Wycombe | 0 | 1 | Leeds | S Attwell |
| 18/08/2009 | Wycombe | 1 | 1 | Southend | J Linington |
| 22/08/2009 | Norwich | 5 | 2 | Wycombe | J Moss |
| 29/08/2009 | Wycombe | 2 | 1 | Bristol Rvs | P Gibbs |
| 05/09/2009 | Brighton | 1 | 0 | Wycombe | G Ward |
| 12/09/2009 | Hartlepool | 1 | 1 | Wycombe | A Taylor |
| 19/09/2009 | Wycombe | 0 | 1 | Milton Keynes Dons | G Hegley |
| 26/09/2009 | Swindon | 1 | 1 | Wycombe | A Hall |
| 29/09/2009 | Wycombe | 0 | 1 | Tranmere | F Graham |
| 03/10/2009 | Wycombe | 0 | 1 | Leyton Orient | J Singh |
| 10/10/2009 | Gillingham | 3 | 2 | Wycombe | P Crossley |
| 17/10/2009 | Wycombe | 1 | 1 | Colchester | C Sarginson |
| 24/10/2009 | Exeter | 1 | 1 | Wycombe | S Rushton |
| 31/10/2009 | Wycombe | 2 | 3 | Walsall | J Waugh |
| 14/11/2009 | Huddersfield | 6 | 0 | Wycombe | M Oliver |
| 21/11/2009 | Millwall | 0 | 2 | Wycombe | R Booth |
| 24/11/2009 | Wycombe | 1 | 0 | Brentford | K Stroud |
| 01/12/2009 | Southampton | 1 | 0 | Wycombe | D Whitestone |
| 05/12/2009 | Wycombe | 2 | 1 | Stockport | D Sheldrake |
| 12/12/2009 | Carlisle | 1 | 0 | Wycombe | P Quinn |
| 19/12/2009 | Wycombe | 2 | 2 | Oldham | D McDermid |
| 26/12/2009 | Yeovil | 4 | 0 | Wycombe | R East |
| 28/12/2009 | Wycombe | 2 | 5 | Brighton | S Rushton |
| 02/01/2010 | Wycombe | 0 | 1 | Norwich | P Miller |
| 09/01/2010 | Leeds | 1 | 1 | Wycombe | D Webb |
| 16/01/2010 | Wycombe | 1 | 2 | Charlton | K Evans |
| 23/01/2010 | Southend | 1 | 1 | Wycombe | D Whitestone |
| 30/01/2010 | Bristol Rvs | 2 | 3 | Wycombe | R Shoebridge |
| 06/02/2010 | Wycombe | 1 | 4 | Yeovil | S Bratt |
| 13/02/2010 | Brentford | 1 | 1 | Wycombe | C Boyeson |
| 20/02/2010 | Wycombe | 1 | 0 | Millwall | A Hall |
| 23/02/2010 | Wycombe | 0 | 0 | Southampton | D Deadman |
| 27/02/2010 | Stockport | 4 | 3 | Wycombe | C Webster |
| 06/03/2010 | Wycombe | 0 | 0 | Carlisle | P Crossley |
| 13/03/2010 | Oldham | 2 | 2 | Wycombe | E Ilderton |
| 20/03/2010 | Wycombe | 2 | 2 | Exeter | P Quinn |
| 27/03/2010 | Colchester | 1 | 1 | Wycombe | S Cook |
| 03/04/2010 | Wycombe | 1 | 2 | Huddersfield | D Phillips |
| 05/04/2010 | Walsall | 2 | 1 | Wycombe | G Hegley |
| 10/04/2010 | Wycombe | 2 | 0 | Hartlepool | D Sheldrake |
| 13/04/2010 | Tranmere | 0 | 3 | Wycombe | A Haines |
| 17/04/2010 | Milton Keynes Dons | 2 | 3 | Wycombe | S Mathieson |
| 24/04/2010 | Wycombe | 2 | 2 | Swindon | S Attwell |
| 01/05/2010 | Leyton Orient | 2 | 0 | Wycombe | A Hall |
| 08/05/2010 | Wycombe | 3 | 0 | Gillingham | P Taylor |