Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Southend | 2 | 1 | Blackburn | L Swabey |
| 12/08/2017 | Rotherham | 5 | 0 | Southend | M Salisbury |
| 19/08/2017 | Southend | 1 | 1 | Plymouth | D Whitestone |
| 26/08/2017 | Gillingham | 3 | 3 | Southend | C Breakspear |
| 02/09/2017 | Southend | 0 | 0 | Rochdale | T Robinson |
| 09/09/2017 | Charlton | 2 | 1 | Southend | C Ward |
| 12/09/2017 | Shrewsbury | 1 | 0 | Southend | R Joyce |
| 16/09/2017 | Southend | 2 | 2 | Northampton | N Kinseley |
| 23/09/2017 | Fleetwood Town | 2 | 4 | Southend | C Boyeson |
| 26/09/2017 | Southend | 1 | 0 | AFC Wimbledon | G Horwood |
| 30/09/2017 | Southend | 2 | 1 | Blackpool | J Brooks |
| 07/10/2017 | Doncaster | 4 | 1 | Southend | D Handley |
| 14/10/2017 | Wigan | 3 | 0 | Southend | J Busby |
| 17/10/2017 | Southend | 1 | 1 | Peterboro | K Johnson |
| 21/10/2017 | Southend | 1 | 0 | Bury | G Ward |
| 28/10/2017 | Walsall | 0 | 1 | Southend | D Drysdale |
| 18/11/2017 | Portsmouth | 1 | 0 | Southend | C Boyeson |
| 21/11/2017 | Milton Keynes Dons | 1 | 1 | Southend | T Robinson |
| 25/11/2017 | Southend | 1 | 1 | Oxford | D Whitestone |
| 02/12/2017 | Southend | 2 | 0 | Oldham | C Breakspear |
| 09/12/2017 | Bristol Rvs | 3 | 0 | Southend | T Nield |
| 16/12/2017 | Southend | 1 | 2 | Bradford | K Stroud |
| 23/12/2017 | Scunthorpe | 3 | 1 | Southend | M Coy |
| 26/12/2017 | Southend | 3 | 1 | Charlton | D Drysdale |
| 30/12/2017 | Southend | 1 | 2 | Shrewsbury | G Ward |
| 01/01/2018 | AFC Wimbledon | 2 | 0 | Southend | J Busby |
| 06/01/2018 | Northampton | 3 | 1 | Southend | M Salisbury |
| 13/01/2018 | Southend | 1 | 2 | Fleetwood Town | A Coggins |
| 27/01/2018 | Southend | 3 | 2 | Scunthorpe | C Hicks |
| 03/02/2018 | Peterboro | 0 | 1 | Southend | D Whitestone |
| 10/02/2018 | Southend | 3 | 1 | Wigan | A Woolmer |
| 13/02/2018 | Bury | 0 | 0 | Southend | M Coy |
| 17/02/2018 | Southend | 3 | 1 | Portsmouth | L Probert |
| 03/03/2018 | Southend | 0 | 3 | Walsall | C Breakspear |
| 10/03/2018 | Southend | 0 | 0 | Doncaster | K Johnson |
| 13/03/2018 | Rochdale | 0 | 0 | Southend | E Ilderton |
| 17/03/2018 | Blackpool | 1 | 1 | Southend | A Haines |
| 24/03/2018 | Southend | 2 | 0 | Rotherham | B Huxtable |
| 30/03/2018 | Plymouth | 4 | 0 | Southend | B Malone |
| 02/04/2018 | Southend | 4 | 0 | Gillingham | G Salisbury |
| 07/04/2018 | Blackburn | 1 | 0 | Southend | A Woolmer |
| 14/04/2018 | Oxford | 2 | 0 | Southend | D Handley |
| 21/04/2018 | Southend | 4 | 0 | Milton Keynes Dons | G Ward |
| 24/04/2018 | Oldham | 0 | 3 | Southend | D Webb |
| 28/04/2018 | Bradford | 0 | 2 | Southend | T Kettle |
| 05/05/2018 | Southend | 0 | 0 | Bristol Rvs | A Coggins |