Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Southend | 1 | 1 | Stockport | I Williamson |
| 14/08/2010 | Aldershot | 1 | 0 | Southend | G Horwood |
| 21/08/2010 | Southend | 1 | 3 | Port Vale | R East |
| 27/08/2010 | Bradford | 0 | 2 | Southend | P Tierney |
| 04/09/2010 | Southend | 2 | 1 | Torquay | D Whitestone |
| 11/09/2010 | Northampton | 2 | 1 | Southend | M Haywood |
| 18/09/2010 | Southend | 2 | 3 | Morecambe | M Russell |
| 25/09/2010 | Hereford | 1 | 3 | Southend | K Evans |
| 28/09/2010 | Gillingham | 0 | 0 | Southend | D McDermid |
| 02/10/2010 | Southend | 1 | 0 | Lincoln | D Sheldrake |
| 09/10/2010 | Chesterfield | 2 | 1 | Southend | D Coote |
| 16/10/2010 | Southend | 0 | 2 | Crewe | A Woolmer |
| 23/10/2010 | Bury | 1 | 0 | Southend | M Brown |
| 30/10/2010 | Southend | 1 | 0 | Rotherham | P Crossley |
| 13/11/2010 | Southend | 1 | 1 | Accrington | G Sutton |
| 20/11/2010 | Shrewsbury | 1 | 1 | Southend | R Shoebridge |
| 23/11/2010 | Stevenage | 1 | 1 | Southend | S Hooper |
| 11/12/2010 | Burton | 3 | 1 | Southend | I Williamson |
| 14/12/2010 | Cheltenham | 0 | 2 | Southend | B Malone |
| 01/01/2011 | Oxford | 0 | 2 | Southend | C Sarginson |
| 03/01/2011 | Southend | 1 | 2 | Cheltenham | P Gibbs |
| 08/01/2011 | Southend | 2 | 3 | Chesterfield | R East |
| 15/01/2011 | Rotherham | 1 | 2 | Southend | S Mathieson |
| 21/01/2011 | Southend | 1 | 1 | Bury | P Miller |
| 25/01/2011 | Southend | 4 | 1 | Macclesfield | M Russell |
| 29/01/2011 | Barnet | 0 | 2 | Southend | T Kettle |
| 01/02/2011 | Southend | 2 | 1 | Oxford | K Hill |
| 05/02/2011 | Southend | 0 | 2 | Shrewsbury | G Salisbury |
| 15/02/2011 | Southend | 3 | 2 | Wycombe | A Woolmer |
| 19/02/2011 | Torquay | 1 | 1 | Southend | D Coote |
| 22/02/2011 | Southend | 2 | 1 | Barnet | D Phillips |
| 26/02/2011 | Southend | 1 | 1 | Northampton | R Booth |
| 05/03/2011 | Morecambe | 2 | 1 | Southend | C Sarginson |
| 08/03/2011 | Southend | 2 | 2 | Gillingham | B Malone |
| 12/03/2011 | Lincoln | 2 | 1 | Southend | P Quinn |
| 15/03/2011 | Crewe | 1 | 0 | Southend | G Eltringham |
| 18/03/2011 | Southend | 4 | 0 | Hereford | K Evans |
| 26/03/2011 | Stockport | 2 | 1 | Southend | C Pawson |
| 02/04/2011 | Southend | 0 | 0 | Aldershot | R Lewis |
| 05/04/2011 | Accrington | 3 | 1 | Southend | D Webb |
| 09/04/2011 | Port Vale | 1 | 1 | Southend | P Gibbs |
| 15/04/2011 | Southend | 4 | 0 | Bradford | M Brown |
| 22/04/2011 | Southend | 1 | 0 | Stevenage | D Coote |
| 25/04/2011 | Macclesfield | 0 | 0 | Southend | B Malone |
| 30/04/2011 | Southend | 1 | 1 | Burton | R Madley |
| 07/05/2011 | Wycombe | 3 | 1 | Southend | N Swarbrick |