Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 12/08/2018 | Southampton | 0 | 0 | Burnley | G Scott |
| 18/08/2018 | Everton | 2 | 1 | Southampton | L Mason |
| 25/08/2018 | Southampton | 1 | 2 | Leicester | J Moss |
| 01/09/2018 | Crystal Palace | 0 | 2 | Southampton | M Atkinson |
| 17/09/2018 | Southampton | 2 | 2 | Brighton | A Taylor |
| 22/09/2018 | Liverpool | 3 | 0 | Southampton | P Tierney |
| 29/09/2018 | Wolves | 2 | 0 | Southampton | S Attwell |
| 07/10/2018 | Southampton | 0 | 3 | Chelsea | C Pawson |
| 20/10/2018 | Bournemouth | 0 | 0 | Southampton | L Probert |
| 27/10/2018 | Southampton | 0 | 0 | Newcastle | C Kavanagh |
| 04/11/2018 | Man City | 6 | 1 | Southampton | L Mason |
| 10/11/2018 | Southampton | 1 | 1 | Watford | S Hooper |
| 24/11/2018 | Fulham | 3 | 2 | Southampton | M Oliver |
| 01/12/2018 | Southampton | 2 | 2 | Man United | K Friend |
| 05/12/2018 | Tottenham | 3 | 1 | Southampton | A Taylor |
| 08/12/2018 | Cardiff | 1 | 0 | Southampton | J Moss |
| 16/12/2018 | Southampton | 3 | 2 | Arsenal | C Kavanagh |
| 22/12/2018 | Huddersfield | 1 | 3 | Southampton | S Attwell |
| 27/12/2018 | Southampton | 1 | 2 | West Ham | C Pawson |
| 30/12/2018 | Southampton | 1 | 3 | Man City | P Tierney |
| 02/01/2019 | Chelsea | 0 | 0 | Southampton | J Moss |
| 12/01/2019 | Leicester | 1 | 2 | Southampton | M Oliver |
| 19/01/2019 | Southampton | 2 | 1 | Everton | G Scott |
| 30/01/2019 | Southampton | 1 | 1 | Crystal Palace | A Marriner |
| 02/02/2019 | Burnley | 1 | 1 | Southampton | A Taylor |
| 09/02/2019 | Southampton | 1 | 2 | Cardiff | M Atkinson |
| 24/02/2019 | Arsenal | 2 | 0 | Southampton | G Scott |
| 27/02/2019 | Southampton | 2 | 0 | Fulham | A Taylor |
| 02/03/2019 | Man United | 3 | 2 | Southampton | S Attwell |
| 09/03/2019 | Southampton | 2 | 1 | Tottenham | K Friend |
| 30/03/2019 | Brighton | 0 | 1 | Southampton | M Oliver |
| 05/04/2019 | Southampton | 1 | 3 | Liverpool | P Tierney |
| 13/04/2019 | Southampton | 3 | 1 | Wolves | J Moss |
| 20/04/2019 | Newcastle | 3 | 1 | Southampton | A Taylor |
| 23/04/2019 | Watford | 1 | 1 | Southampton | M Dean |
| 27/04/2019 | Southampton | 3 | 3 | Bournemouth | G Scott |
| 04/05/2019 | West Ham | 3 | 0 | Southampton | S Attwell |
| 12/05/2019 | Southampton | 1 | 1 | Huddersfield | L Probert |