Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Southampton | 3 | 1 | Leeds | K Wright |
| 13/08/2011 | Barnsley | 0 | 1 | Southampton | C Webster |
| 16/08/2011 | Ipswich | 2 | 5 | Southampton | J Moss |
| 20/08/2011 | Southampton | 1 | 0 | Millwall | A D'Urso |
| 27/08/2011 | Leicester | 3 | 2 | Southampton | S Mathieson |
| 10/09/2011 | Southampton | 3 | 2 | Nott'm Forest | I Williamson |
| 18/09/2011 | Southampton | 4 | 1 | Birmingham | D Whitestone |
| 24/09/2011 | Burnley | 1 | 1 | Southampton | A Taylor |
| 28/09/2011 | Cardiff | 2 | 1 | Southampton | P Gibbs |
| 01/10/2011 | Southampton | 4 | 0 | Watford | C Boyeson |
| 15/10/2011 | Derby | 1 | 1 | Southampton | M Brown |
| 18/10/2011 | Southampton | 1 | 0 | West Ham | D Deadman |
| 22/10/2011 | Reading | 1 | 1 | Southampton | J Moss |
| 29/10/2011 | Southampton | 3 | 0 | Middlesbrough | R East |
| 01/11/2011 | Southampton | 2 | 1 | Peterboro | G Ward |
| 05/11/2011 | Coventry | 2 | 4 | Southampton | M Naylor |
| 19/11/2011 | Southampton | 3 | 0 | Brighton | P Walton |
| 26/11/2011 | Bristol City | 2 | 0 | Southampton | C Sarginson |
| 29/11/2011 | Southampton | 2 | 1 | Hull | O Langford |
| 03/12/2011 | Doncaster | 1 | 0 | Southampton | A Haines |
| 10/12/2011 | Southampton | 2 | 2 | Blackpool | G Eltringham |
| 18/12/2011 | Portsmouth | 1 | 1 | Southampton | M Halsey |
| 26/12/2011 | Southampton | 2 | 0 | Crystal Palace | G Salisbury |
| 30/12/2011 | Southampton | 0 | 1 | Bristol City | D Deadman |
| 02/01/2012 | Brighton | 3 | 0 | Southampton | A D'Urso |
| 14/01/2012 | Nott'm Forest | 0 | 3 | Southampton | E Ilderton |
| 23/01/2012 | Southampton | 0 | 2 | Leicester | N Swarbrick |
| 31/01/2012 | Southampton | 1 | 1 | Cardiff | M Haywood |
| 04/02/2012 | Birmingham | 0 | 0 | Southampton | P Dowd |
| 11/02/2012 | Southampton | 2 | 0 | Burnley | T Kettle |
| 14/02/2012 | West Ham | 1 | 1 | Southampton | L Probert |
| 18/02/2012 | Southampton | 4 | 0 | Derby | G Scott |
| 25/02/2012 | Watford | 0 | 3 | Southampton | A Bates |
| 03/03/2012 | Leeds | 0 | 1 | Southampton | N Miller |
| 06/03/2012 | Southampton | 1 | 1 | Ipswich | D Drysdale |
| 10/03/2012 | Southampton | 2 | 0 | Barnsley | D Phillips |
| 17/03/2012 | Millwall | 2 | 3 | Southampton | F Graham |
| 20/03/2012 | Hull | 0 | 2 | Southampton | D Webb |
| 24/03/2012 | Southampton | 2 | 0 | Doncaster | D McDermid |
| 31/03/2012 | Blackpool | 3 | 0 | Southampton | D Whitestone |
| 07/04/2012 | Southampton | 2 | 2 | Portsmouth | N Swarbrick |
| 09/04/2012 | Crystal Palace | 0 | 2 | Southampton | G Sutton |
| 13/04/2012 | Southampton | 1 | 3 | Reading | M Dean |
| 17/04/2012 | Peterboro | 1 | 3 | Southampton | J Waugh |
| 21/04/2012 | Middlesbrough | 2 | 1 | Southampton | A Bates |
| 28/04/2012 | Southampton | 4 | 0 | Coventry | A Taylor |