Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Rotherham | 2 | 1 | Lincoln | R Shoebridge |
| 14/08/2010 | Morecambe | 0 | 0 | Rotherham | D Webb |
| 21/08/2010 | Rotherham | 6 | 4 | Cheltenham | P Tierney |
| 28/08/2010 | Hereford | 0 | 1 | Rotherham | S Rushton |
| 04/09/2010 | Shrewsbury | 1 | 0 | Rotherham | T Kettle |
| 11/09/2010 | Rotherham | 3 | 3 | Burton | G Salisbury |
| 18/09/2010 | Barnet | 1 | 4 | Rotherham | B Malone |
| 25/09/2010 | Rotherham | 1 | 0 | Chesterfield | A Haines |
| 28/09/2010 | Rotherham | 0 | 0 | Bradford | C Webster |
| 02/10/2010 | Bury | 1 | 1 | Rotherham | G Sutton |
| 09/10/2010 | Rotherham | 1 | 1 | Stevenage | G Scott |
| 16/10/2010 | Accrington | 2 | 3 | Rotherham | G Eltringham |
| 23/10/2010 | Rotherham | 3 | 4 | Wycombe | P Quinn |
| 30/10/2010 | Southend | 1 | 0 | Rotherham | P Crossley |
| 02/11/2010 | Rotherham | 1 | 1 | Macclesfield | N Miller |
| 13/11/2010 | Rotherham | 2 | 1 | Oxford | D Drysdale |
| 20/11/2010 | Crewe | 0 | 1 | Rotherham | N Swarbrick |
| 23/11/2010 | Rotherham | 2 | 2 | Northampton | R Lewis |
| 11/12/2010 | Rotherham | 1 | 0 | Aldershot | G Sutton |
| 01/01/2011 | Rotherham | 5 | 0 | Port Vale | G Salisbury |
| 03/01/2011 | Macclesfield | 0 | 2 | Rotherham | E Ilderton |
| 11/01/2011 | Stockport | 3 | 3 | Rotherham | D Coote |
| 15/01/2011 | Rotherham | 1 | 2 | Southend | S Mathieson |
| 22/01/2011 | Wycombe | 1 | 0 | Rotherham | D Phillips |
| 25/01/2011 | Stevenage | 3 | 0 | Rotherham | G Ward |
| 29/01/2011 | Rotherham | 4 | 0 | Stockport | K Wright |
| 01/02/2011 | Port Vale | 1 | 0 | Rotherham | K Evans |
| 05/02/2011 | Rotherham | 3 | 1 | Crewe | D Foster |
| 08/02/2011 | Gillingham | 3 | 1 | Rotherham | D Sheldrake |
| 12/02/2011 | Oxford | 2 | 1 | Rotherham | S Hooper |
| 15/02/2011 | Rotherham | 2 | 0 | Accrington | M Brown |
| 26/02/2011 | Burton | 2 | 4 | Rotherham | G Horwood |
| 01/03/2011 | Torquay | 1 | 1 | Rotherham | T Kettle |
| 05/03/2011 | Rotherham | 0 | 0 | Barnet | G Eltringham |
| 08/03/2011 | Bradford | 2 | 1 | Rotherham | G Hegley |
| 12/03/2011 | Rotherham | 0 | 0 | Bury | D Webb |
| 18/03/2011 | Chesterfield | 5 | 0 | Rotherham | A D'Urso |
| 25/03/2011 | Lincoln | 0 | 6 | Rotherham | M Russell |
| 29/03/2011 | Rotherham | 1 | 3 | Shrewsbury | D Phillips |
| 02/04/2011 | Rotherham | 0 | 1 | Morecambe | S Rushton |
| 09/04/2011 | Cheltenham | 1 | 1 | Rotherham | I Williamson |
| 16/04/2011 | Rotherham | 0 | 0 | Hereford | C Boyeson |
| 22/04/2011 | Northampton | 2 | 2 | Rotherham | K Stroud |
| 25/04/2011 | Rotherham | 0 | 1 | Gillingham | O Langford |
| 30/04/2011 | Aldershot | 2 | 2 | Rotherham | K Evans |
| 07/05/2011 | Rotherham | 3 | 1 | Torquay | A Woolmer |