Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Walsall | 2 | 1 | Plymouth | A Haines |
| 11/08/2018 | Plymouth | 1 | 1 | Southend | J Busby |
| 18/08/2018 | Coventry | 1 | 0 | Plymouth | D Drysdale |
| 21/08/2018 | Plymouth | 1 | 1 | Wycombe | O Yates |
| 25/08/2018 | Plymouth | 1 | 5 | Peterboro | C Sarginson |
| 01/09/2018 | Portsmouth | 3 | 0 | Plymouth | T Nield |
| 08/09/2018 | Bristol Rvs | 0 | 0 | Plymouth | M Salisbury |
| 15/09/2018 | Plymouth | 0 | 1 | Blackpool | N Hair |
| 22/09/2018 | Charlton | 2 | 1 | Plymouth | D Whitestone |
| 29/09/2018 | Plymouth | 2 | 3 | Doncaster | K Johnson |
| 02/10/2018 | Barnsley | 1 | 1 | Plymouth | C Boyeson |
| 06/10/2018 | Plymouth | 1 | 0 | AFC Wimbledon | A Young |
| 13/10/2018 | Oxford | 2 | 0 | Plymouth | A Woolmer |
| 20/10/2018 | Plymouth | 2 | 3 | Burton | T Bramall |
| 23/10/2018 | Plymouth | 3 | 1 | Gillingham | D England |
| 27/10/2018 | Scunthorpe | 1 | 4 | Plymouth | S Oldham |
| 03/11/2018 | Plymouth | 0 | 2 | Sunderland | C Boyeson |
| 17/11/2018 | Luton | 5 | 1 | Plymouth | D England |
| 24/11/2018 | Plymouth | 2 | 1 | Fleetwood Town | C Breakspear |
| 27/11/2018 | Shrewsbury | 2 | 0 | Plymouth | M Donohue |
| 08/12/2018 | Plymouth | 3 | 3 | Bradford | R Lewis |
| 15/12/2018 | Rochdale | 1 | 2 | Plymouth | C Boyeson |
| 22/12/2018 | Plymouth | 0 | 3 | Accrington | K Johnson |
| 26/12/2018 | AFC Wimbledon | 2 | 1 | Plymouth | C Hicks |
| 29/12/2018 | Burton | 1 | 1 | Plymouth | E Ilderton |
| 01/01/2019 | Plymouth | 3 | 0 | Oxford | B Huxtable |
| 12/01/2019 | Southend | 2 | 3 | Plymouth | G Salisbury |
| 19/01/2019 | Plymouth | 2 | 1 | Coventry | T Kettle |
| 22/01/2019 | Plymouth | 2 | 1 | Walsall | J Busby |
| 26/01/2019 | Wycombe | 1 | 0 | Plymouth | S Oldham |
| 02/02/2019 | Peterboro | 0 | 1 | Plymouth | P Wright |
| 09/02/2019 | Plymouth | 1 | 1 | Portsmouth | B Toner |
| 16/02/2019 | Bradford | 0 | 0 | Plymouth | E Ilderton |
| 23/02/2019 | Plymouth | 5 | 1 | Rochdale | C Sarginson |
| 02/03/2019 | Sunderland | 2 | 0 | Plymouth | G Salisbury |
| 09/03/2019 | Plymouth | 0 | 0 | Luton | D Drysdale |
| 12/03/2019 | Plymouth | 2 | 1 | Shrewsbury | B Huxtable |
| 16/03/2019 | Fleetwood Town | 2 | 0 | Plymouth | J Busby |
| 23/03/2019 | Plymouth | 2 | 2 | Bristol Rvs | R East |
| 30/03/2019 | Blackpool | 2 | 2 | Plymouth | S Stockbridge |
| 06/04/2019 | Plymouth | 0 | 2 | Charlton | C Breakspear |
| 13/04/2019 | Doncaster | 2 | 0 | Plymouth | O Yates |
| 19/04/2019 | Gillingham | 3 | 1 | Plymouth | A Coggins |
| 22/04/2019 | Plymouth | 0 | 3 | Barnsley | S Martin |
| 27/04/2019 | Accrington | 5 | 1 | Plymouth | C Hicks |
| 04/05/2019 | Plymouth | 3 | 2 | Scunthorpe | R East |