Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Peterboro | 2 | 1 | Plymouth | J Busby |
| 12/08/2017 | Plymouth | 2 | 0 | Charlton | J Brooks |
| 19/08/2017 | Southend | 1 | 1 | Plymouth | D Whitestone |
| 26/08/2017 | Plymouth | 0 | 4 | Scunthorpe | C Sarginson |
| 02/09/2017 | Walsall | 2 | 1 | Plymouth | R Jones |
| 09/09/2017 | Plymouth | 0 | 1 | Milton Keynes Dons | C Breakspear |
| 12/09/2017 | Plymouth | 1 | 3 | Blackpool | K Johnson |
| 16/09/2017 | Bury | 0 | 0 | Plymouth | A Backhouse |
| 23/09/2017 | Plymouth | 0 | 3 | Doncaster | N Kinseley |
| 26/09/2017 | Wigan | 1 | 0 | Plymouth | S Stockbridge |
| 30/09/2017 | Bristol Rvs | 2 | 1 | Plymouth | G Salisbury |
| 07/10/2017 | Plymouth | 1 | 2 | Fleetwood Town | C Hicks |
| 14/10/2017 | Plymouth | 1 | 1 | Shrewsbury | M Heywood |
| 17/10/2017 | Blackburn | 1 | 1 | Plymouth | E Ilderton |
| 21/10/2017 | AFC Wimbledon | 0 | 1 | Plymouth | M Coy |
| 28/10/2017 | Plymouth | 1 | 1 | Rochdale | G Ward |
| 11/11/2017 | Bradford | 0 | 1 | Plymouth | C Boyeson |
| 18/11/2017 | Plymouth | 0 | 4 | Oxford | G Horwood |
| 21/11/2017 | Plymouth | 2 | 0 | Northampton | A Coggins |
| 25/11/2017 | Portsmouth | 1 | 0 | Plymouth | R Madley |
| 09/12/2017 | Plymouth | 2 | 1 | Gillingham | D Handley |
| 16/12/2017 | Rotherham | 1 | 1 | Plymouth | A Haines |
| 23/12/2017 | Plymouth | 4 | 1 | Oldham | L Collins |
| 26/12/2017 | Milton Keynes Dons | 0 | 1 | Plymouth | J Busby |
| 30/12/2017 | Blackpool | 2 | 2 | Plymouth | J Brooks |
| 01/01/2018 | Plymouth | 1 | 0 | Walsall | K Johnson |
| 06/01/2018 | Plymouth | 3 | 0 | Bury | T Kettle |
| 13/01/2018 | Doncaster | 1 | 1 | Plymouth | A Haines |
| 20/01/2018 | Plymouth | 1 | 3 | Wigan | G Ward |
| 27/01/2018 | Oldham | 1 | 2 | Plymouth | M Coy |
| 03/02/2018 | Plymouth | 2 | 0 | Blackburn | C Breakspear |
| 10/02/2018 | Shrewsbury | 1 | 2 | Plymouth | B Toner |
| 13/02/2018 | Plymouth | 4 | 2 | AFC Wimbledon | B Huxtable |
| 17/02/2018 | Oxford | 0 | 1 | Plymouth | M Heywood |
| 24/02/2018 | Plymouth | 1 | 0 | Bradford | G Salisbury |
| 10/03/2018 | Fleetwood Town | 1 | 1 | Plymouth | D Handley |
| 17/03/2018 | Plymouth | 3 | 2 | Bristol Rvs | J Brooks |
| 24/03/2018 | Charlton | 2 | 0 | Plymouth | J Busby |
| 30/03/2018 | Plymouth | 4 | 0 | Southend | B Malone |
| 07/04/2018 | Plymouth | 2 | 1 | Peterboro | C Hicks |
| 14/04/2018 | Plymouth | 0 | 0 | Portsmouth | D Whitestone |
| 21/04/2018 | Northampton | 2 | 0 | Plymouth | L Collins |
| 24/04/2018 | Rochdale | 1 | 1 | Plymouth | D Drysdale |
| 28/04/2018 | Plymouth | 2 | 1 | Rotherham | D Handley |
| 01/05/2018 | Scunthorpe | 2 | 0 | Plymouth | B Toner |
| 05/05/2018 | Gillingham | 5 | 2 | Plymouth | B Malone |