Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | AFC Wimbledon | 0 | 2 | Plymouth | B Toner |
| 15/08/2015 | Plymouth | 1 | 2 | Portsmouth | S Martin |
| 18/08/2015 | Plymouth | 4 | 1 | Carlisle | O Langford |
| 22/08/2015 | Northampton | 0 | 2 | Plymouth | N Kinseley |
| 29/08/2015 | Plymouth | 1 | 0 | Newport County | A Davies |
| 05/09/2015 | Stevenage | 2 | 1 | Plymouth | G Sutton |
| 12/09/2015 | Wycombe | 1 | 2 | Plymouth | T Robinson |
| 19/09/2015 | Plymouth | 1 | 1 | Bristol Rvs | C Sarginson |
| 26/09/2015 | Mansfield | 0 | 0 | Plymouth | M Brown |
| 29/09/2015 | Plymouth | 2 | 1 | Barnet | S Hooper |
| 03/10/2015 | Plymouth | 2 | 1 | Crawley Town | S Attwell |
| 11/10/2015 | Notts County | 0 | 2 | Plymouth | J Simpson |
| 17/10/2015 | Plymouth | 1 | 0 | Accrington | N Kinseley |
| 20/10/2015 | Oxford | 1 | 0 | Plymouth | K Stroud |
| 24/10/2015 | Luton | 1 | 2 | Plymouth | R Joyce |
| 31/10/2015 | Plymouth | 2 | 0 | Morecambe | M Bull |
| 14/11/2015 | York | 1 | 2 | Plymouth | R Clark |
| 21/11/2015 | Plymouth | 1 | 2 | Exeter | G Scott |
| 24/11/2015 | Plymouth | 1 | 1 | Leyton Orient | A Woolmer |
| 28/11/2015 | Dag and Red | 1 | 1 | Plymouth | D Deadman |
| 12/12/2015 | Plymouth | 1 | 2 | Cambridge | T Robinson |
| 19/12/2015 | Hartlepool | 1 | 2 | Plymouth | G Salisbury |
| 26/12/2015 | Plymouth | 1 | 0 | Yeovil | C Breakspear |
| 28/12/2015 | Newport County | 1 | 2 | Plymouth | F Graham |
| 02/01/2016 | Carlisle | 0 | 2 | Plymouth | S Stockbridge |
| 12/01/2016 | Plymouth | 1 | 2 | Northampton | K Stroud |
| 16/01/2016 | Plymouth | 3 | 2 | Stevenage | J Linington |
| 23/01/2016 | Bristol Rvs | 1 | 1 | Plymouth | O Langford |
| 30/01/2016 | Plymouth | 0 | 1 | Wycombe | P Gibbs |
| 13/02/2016 | Plymouth | 3 | 0 | Mansfield | B Malone |
| 20/02/2016 | Crawley Town | 1 | 1 | Plymouth | P Bankes |
| 23/02/2016 | Yeovil | 0 | 0 | Plymouth | L Collins |
| 27/02/2016 | Plymouth | 1 | 0 | Notts County | I Williamson |
| 01/03/2016 | Barnet | 1 | 0 | Plymouth | G Ward |
| 05/03/2016 | Plymouth | 2 | 2 | Oxford | J Adcock |
| 12/03/2016 | Accrington | 2 | 1 | Plymouth | M Heywood |
| 19/03/2016 | Plymouth | 0 | 1 | Luton | D Bond |
| 25/03/2016 | Morecambe | 0 | 2 | Plymouth | D Webb |
| 28/03/2016 | Plymouth | 3 | 2 | York | D Whitestone |
| 02/04/2016 | Exeter | 2 | 1 | Plymouth | K Stroud |
| 09/04/2016 | Plymouth | 1 | 2 | AFC Wimbledon | D Drysdale |
| 16/04/2016 | Portsmouth | 1 | 2 | Plymouth | C Sarginson |
| 19/04/2016 | Leyton Orient | 1 | 3 | Plymouth | T Robinson |
| 23/04/2016 | Plymouth | 2 | 3 | Dag and Red | J Adcock |
| 30/04/2016 | Cambridge | 2 | 2 | Plymouth | T Kettle |
| 07/05/2016 | Plymouth | 5 | 0 | Hartlepool | D Deadman |