Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Shrewsbury | 1 | 1 | Plymouth | G Eltringham |
| 13/08/2011 | Plymouth | 1 | 4 | Rotherham | D Sheldrake |
| 16/08/2011 | Plymouth | 0 | 2 | AFC Wimbledon | M Heywood |
| 20/08/2011 | Gillingham | 3 | 0 | Plymouth | R Lewis |
| 27/08/2011 | Plymouth | 0 | 1 | Crewe | L Collins |
| 03/09/2011 | Burton | 2 | 1 | Plymouth | A Madley |
| 10/09/2011 | Plymouth | 0 | 2 | Port Vale | C Pawson |
| 13/09/2011 | Barnet | 2 | 0 | Plymouth | M Brown |
| 17/09/2011 | Southend | 2 | 0 | Plymouth | M Naylor |
| 24/09/2011 | Plymouth | 2 | 0 | Macclesfield | R East |
| 01/10/2011 | Crawley Town | 2 | 0 | Plymouth | G Sutton |
| 08/10/2011 | Plymouth | 2 | 2 | Accrington | D Coote |
| 15/10/2011 | Dag and Red | 2 | 3 | Plymouth | C Sarginson |
| 22/10/2011 | Plymouth | 0 | 1 | Swindon | A Woolmer |
| 25/10/2011 | Oxford | 5 | 1 | Plymouth | P Gibbs |
| 29/10/2011 | Cheltenham | 2 | 1 | Plymouth | J Moss |
| 05/11/2011 | Plymouth | 1 | 1 | Morecambe | F Graham |
| 19/11/2011 | Torquay | 3 | 1 | Plymouth | J Waugh |
| 26/11/2011 | Plymouth | 4 | 1 | Northampton | O Langford |
| 10/12/2011 | Bradford | 1 | 1 | Plymouth | B Malone |
| 17/12/2011 | Plymouth | 1 | 1 | Hereford | J Linington |
| 26/12/2011 | Bristol Rvs | 2 | 3 | Plymouth | R East |
| 31/12/2011 | Aldershot | 0 | 0 | Plymouth | D Coote |
| 02/01/2012 | Plymouth | 1 | 2 | Torquay | A Bates |
| 07/01/2012 | Crewe | 3 | 2 | Plymouth | A Madley |
| 14/01/2012 | Plymouth | 2 | 1 | Burton | J Adcock |
| 21/01/2012 | Plymouth | 1 | 1 | Crawley Town | P Gibbs |
| 28/01/2012 | Port Vale | 1 | 0 | Plymouth | I Williamson |
| 04/02/2012 | Plymouth | 2 | 2 | Southend | C Sarginson |
| 14/02/2012 | Plymouth | 0 | 0 | Barnet | B Malone |
| 18/02/2012 | Accrington | 0 | 4 | Plymouth | M Heywood |
| 25/02/2012 | Plymouth | 0 | 0 | Dag and Red | D Whitestone |
| 28/02/2012 | Macclesfield | 1 | 1 | Plymouth | A Haines |
| 03/03/2012 | Plymouth | 0 | 1 | Gillingham | M Brown |
| 06/03/2012 | AFC Wimbledon | 1 | 2 | Plymouth | D McDermid |
| 10/03/2012 | Rotherham | 1 | 0 | Plymouth | C Berry |
| 17/03/2012 | Plymouth | 1 | 0 | Shrewsbury | J Waugh |
| 20/03/2012 | Plymouth | 1 | 1 | Bristol Rvs | M Haywood |
| 24/03/2012 | Northampton | 0 | 0 | Plymouth | D Phillips |
| 31/03/2012 | Plymouth | 1 | 0 | Bradford | A D'Urso |
| 06/04/2012 | Hereford | 1 | 1 | Plymouth | O Langford |
| 09/04/2012 | Plymouth | 1 | 0 | Aldershot | J Linington |
| 14/04/2012 | Swindon | 1 | 0 | Plymouth | S Mathieson |
| 21/04/2012 | Plymouth | 1 | 1 | Oxford | G Sutton |
| 28/04/2012 | Morecambe | 2 | 2 | Plymouth | T Kettle |
| 05/05/2012 | Plymouth | 1 | 2 | Cheltenham | P Gibbs |