Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Southampton | 0 | 1 | Plymouth | J Moss |
| 14/08/2010 | Plymouth | 1 | 1 | Carlisle | R East |
| 21/08/2010 | Walsall | 2 | 1 | Plymouth | K Hill |
| 28/08/2010 | Plymouth | 0 | 3 | Peterboro | A Haines |
| 11/09/2010 | Colchester | 1 | 1 | Plymouth | D McDermid |
| 18/09/2010 | Plymouth | 3 | 2 | Sheffield Weds | A Penn |
| 21/09/2010 | Plymouth | 0 | 2 | Brighton | B Malone |
| 25/09/2010 | Rochdale | 1 | 1 | Plymouth | P Quinn |
| 28/09/2010 | Swindon | 2 | 3 | Plymouth | O Langford |
| 02/10/2010 | Plymouth | 0 | 1 | Hartlepool | S Hooper |
| 09/10/2010 | Plymouth | 2 | 2 | Charlton | C Sarginson |
| 16/10/2010 | Notts County | 2 | 0 | Plymouth | R Lewis |
| 23/10/2010 | Plymouth | 2 | 1 | Huddersfield | M Russell |
| 30/10/2010 | Oldham | 4 | 2 | Plymouth | E Ilderton |
| 02/11/2010 | Plymouth | 3 | 1 | Bristol Rvs | R Shoebridge |
| 13/11/2010 | Tranmere | 1 | 0 | Plymouth | R Madley |
| 20/11/2010 | Plymouth | 1 | 2 | Brentford | P Gibbs |
| 23/11/2010 | Plymouth | 2 | 1 | Dag and Red | R East |
| 11/12/2010 | Plymouth | 2 | 0 | Exeter | G Hegley |
| 28/12/2010 | Plymouth | 1 | 1 | Notts County | S Tanner |
| 01/01/2011 | Plymouth | 0 | 0 | Yeovil | B Malone |
| 04/01/2011 | Bristol Rvs | 2 | 3 | Plymouth | R Booth |
| 08/01/2011 | Bournemouth | 3 | 0 | Plymouth | K Wright |
| 11/01/2011 | Huddersfield | 3 | 2 | Plymouth | P Tierney |
| 15/01/2011 | Plymouth | 0 | 2 | Oldham | P Miller |
| 18/01/2011 | Milton Keynes Dons | 1 | 3 | Plymouth | G Eltringham |
| 22/01/2011 | Charlton | 2 | 0 | Plymouth | F Graham |
| 29/01/2011 | Plymouth | 1 | 2 | Bournemouth | A D'Urso |
| 01/02/2011 | Yeovil | 1 | 0 | Plymouth | J Linington |
| 05/02/2011 | Brentford | 2 | 0 | Plymouth | D Drysdale |
| 12/02/2011 | Plymouth | 1 | 3 | Tranmere | G Horwood |
| 22/02/2011 | Brighton | 4 | 0 | Plymouth | G Russell |
| 26/02/2011 | Plymouth | 2 | 1 | Colchester | O Langford |
| 05/03/2011 | Sheffield Weds | 2 | 4 | Plymouth | I Williamson |
| 08/03/2011 | Plymouth | 1 | 0 | Swindon | P Crossley |
| 12/03/2011 | Hartlepool | 2 | 0 | Plymouth | C Pawson |
| 15/03/2011 | Carlisle | 1 | 1 | Plymouth | N Swarbrick |
| 19/03/2011 | Plymouth | 0 | 1 | Rochdale | S Hooper |
| 05/04/2011 | Leyton Orient | 2 | 0 | Plymouth | M Naylor |
| 09/04/2011 | Plymouth | 2 | 0 | Walsall | K Stroud |
| 16/04/2011 | Peterboro | 2 | 1 | Plymouth | N Miller |
| 22/04/2011 | Dag and Red | 0 | 1 | Plymouth | J Linington |
| 25/04/2011 | Plymouth | 1 | 0 | Milton Keynes Dons | S Tanner |
| 30/04/2011 | Exeter | 1 | 0 | Plymouth | M Halsey |
| 02/05/2011 | Plymouth | 1 | 3 | Southampton | A Woolmer |
| 07/05/2011 | Plymouth | 1 | 4 | Leyton Orient | D Whitestone |