Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Exeter | 2 | 2 | Colchester | P Gibbs |
| 21/08/2010 | Exeter | 2 | 2 | Bristol Rvs | M Russell |
| 28/08/2010 | Leyton Orient | 3 | 0 | Exeter | P Miller |
| 04/09/2010 | Exeter | 1 | 0 | Charlton | D Phillips |
| 11/09/2010 | Hartlepool | 2 | 3 | Exeter | J Moss |
| 18/09/2010 | Exeter | 2 | 2 | Peterboro | C Sarginson |
| 21/09/2010 | Dag and Red | 1 | 1 | Exeter | O Langford |
| 25/09/2010 | Yeovil | 1 | 3 | Exeter | I Williamson |
| 28/09/2010 | Bournemouth | 3 | 0 | Exeter | J Linington |
| 02/10/2010 | Exeter | 1 | 0 | Rochdale | S Tanner |
| 09/10/2010 | Walsall | 2 | 1 | Exeter | G Salisbury |
| 16/10/2010 | Exeter | 2 | 1 | Carlisle | S Rushton |
| 23/10/2010 | Milton Keynes Dons | 1 | 0 | Exeter | G Sutton |
| 30/10/2010 | Exeter | 2 | 4 | Brentford | D Deadman |
| 02/11/2010 | Brighton | 3 | 0 | Exeter | K Hill |
| 13/11/2010 | Exeter | 3 | 1 | Notts County | M Heywood |
| 20/11/2010 | Huddersfield | 0 | 1 | Exeter | N Miller |
| 23/11/2010 | Oldham | 3 | 3 | Exeter | D Coote |
| 11/12/2010 | Plymouth | 2 | 0 | Exeter | G Hegley |
| 18/12/2010 | Exeter | 5 | 1 | Sheffield Weds | F Graham |
| 01/01/2011 | Southampton | 4 | 0 | Exeter | D Phillips |
| 03/01/2011 | Exeter | 1 | 2 | Brighton | S Tanner |
| 08/01/2011 | Exeter | 1 | 1 | Milton Keynes Dons | R Lewis |
| 14/01/2011 | Brentford | 1 | 1 | Exeter | R East |
| 22/01/2011 | Exeter | 2 | 1 | Walsall | R Madley |
| 29/01/2011 | Swindon | 0 | 0 | Exeter | K Stroud |
| 01/02/2011 | Exeter | 1 | 2 | Southampton | D McDermid |
| 05/02/2011 | Exeter | 1 | 4 | Huddersfield | I Williamson |
| 12/02/2011 | Notts County | 0 | 2 | Exeter | C Pawson |
| 19/02/2011 | Charlton | 1 | 3 | Exeter | S Tanner |
| 22/02/2011 | Carlisle | 2 | 2 | Exeter | A Haines |
| 26/02/2011 | Exeter | 1 | 2 | Hartlepool | C Sarginson |
| 01/03/2011 | Exeter | 1 | 1 | Tranmere | S Hooper |
| 05/03/2011 | Peterboro | 3 | 0 | Exeter | M Naylor |
| 08/03/2011 | Exeter | 2 | 0 | Bournemouth | G Sutton |
| 12/03/2011 | Rochdale | 0 | 1 | Exeter | D Foster |
| 19/03/2011 | Exeter | 2 | 3 | Yeovil | G Ward |
| 26/03/2011 | Colchester | 5 | 1 | Exeter | K Evans |
| 29/03/2011 | Exeter | 1 | 0 | Swindon | D Coote |
| 02/04/2011 | Exeter | 2 | 1 | Dag and Red | A Bates |
| 09/04/2011 | Bristol Rvs | 0 | 2 | Exeter | J Moss |
| 16/04/2011 | Exeter | 2 | 1 | Leyton Orient | B Malone |
| 22/04/2011 | Exeter | 2 | 0 | Oldham | J Waugh |
| 25/04/2011 | Tranmere | 4 | 0 | Exeter | G Scott |
| 30/04/2011 | Exeter | 1 | 0 | Plymouth | M Halsey |
| 07/05/2011 | Sheffield Weds | 1 | 2 | Exeter | A D'Urso |