Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2009 | Leeds | 2 | 1 | Exeter | N Miller |
| 15/08/2009 | Exeter | 1 | 1 | Norwich | T Bates |
| 18/08/2009 | Exeter | 1 | 1 | Yeovil | C Sarginson |
| 22/08/2009 | Carlisle | 0 | 1 | Exeter | M Oliver |
| 29/08/2009 | Exeter | 1 | 2 | Milton Keynes Dons | A Hall |
| 05/09/2009 | Gillingham | 3 | 0 | Exeter | S Hooper |
| 12/09/2009 | Leyton Orient | 1 | 1 | Exeter | K Hill |
| 19/09/2009 | Exeter | 2 | 1 | Tranmere | D Phillips |
| 26/09/2009 | Charlton | 2 | 1 | Exeter | G Hegley |
| 29/09/2009 | Exeter | 1 | 1 | Swindon | K Stroud |
| 03/10/2009 | Exeter | 3 | 1 | Hartlepool | J Linington |
| 10/10/2009 | Huddersfield | 4 | 0 | Exeter | G Sutton |
| 17/10/2009 | Walsall | 3 | 0 | Exeter | P Tierney |
| 24/10/2009 | Exeter | 1 | 1 | Wycombe | S Rushton |
| 31/10/2009 | Exeter | 3 | 0 | Brentford | D Whitestone |
| 14/11/2009 | Colchester | 2 | 2 | Exeter | P Taylor |
| 21/11/2009 | Stockport | 1 | 3 | Exeter | M Jones |
| 24/11/2009 | Exeter | 1 | 1 | Millwall | S Hooper |
| 01/12/2009 | Bristol Rvs | 1 | 0 | Exeter | A Penn |
| 05/12/2009 | Exeter | 0 | 1 | Brighton | R Shoebridge |
| 12/12/2009 | Oldham | 2 | 0 | Exeter | J Waugh |
| 19/12/2009 | Exeter | 1 | 0 | Southend | R East |
| 26/12/2009 | Southampton | 3 | 1 | Exeter | G Horwood |
| 28/12/2009 | Exeter | 1 | 1 | Gillingham | S Bratt |
| 09/01/2010 | Norwich | 3 | 1 | Exeter | D Deadman |
| 16/01/2010 | Exeter | 2 | 0 | Leeds | G Stott |
| 23/01/2010 | Yeovil | 2 | 1 | Exeter | S Tanner |
| 26/01/2010 | Exeter | 2 | 3 | Carlisle | O Langford |
| 30/01/2010 | Milton Keynes Dons | 1 | 1 | Exeter | S Cook |
| 06/02/2010 | Exeter | 1 | 1 | Southampton | M Haywood |
| 13/02/2010 | Millwall | 1 | 0 | Exeter | P Gibbs |
| 20/02/2010 | Exeter | 0 | 1 | Stockport | G Ward |
| 27/02/2010 | Brighton | 2 | 0 | Exeter | S Rushton |
| 06/03/2010 | Exeter | 1 | 1 | Oldham | S Hooper |
| 13/03/2010 | Southend | 0 | 0 | Exeter | D Sheldrake |
| 17/03/2010 | Exeter | 1 | 0 | Bristol Rvs | A Hall |
| 20/03/2010 | Wycombe | 2 | 2 | Exeter | P Quinn |
| 27/03/2010 | Exeter | 2 | 1 | Walsall | T Kettle |
| 02/04/2010 | Exeter | 2 | 0 | Colchester | P Gibbs |
| 05/04/2010 | Brentford | 0 | 0 | Exeter | M Russell |
| 10/04/2010 | Exeter | 0 | 0 | Leyton Orient | S Mathieson |
| 12/04/2010 | Swindon | 1 | 1 | Exeter | N Swarbrick |
| 17/04/2010 | Tranmere | 3 | 1 | Exeter | G Eltringham |
| 24/04/2010 | Exeter | 1 | 1 | Charlton | D Phillips |
| 01/05/2010 | Hartlepool | 1 | 1 | Exeter | G Salisbury |
| 08/05/2010 | Exeter | 2 | 1 | Huddersfield | R East |