Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Port Vale | 3 | 0 | Cambridge | T Kettle |
| 11/08/2018 | Cambridge | 3 | 2 | Notts County | A Haines |
| 18/08/2018 | Northampton | 2 | 2 | Cambridge | S Stockbridge |
| 21/08/2018 | Cambridge | 0 | 2 | Exeter | C Hicks |
| 25/08/2018 | Cambridge | 0 | 1 | Cheltenham | M Donohue |
| 01/09/2018 | Stevenage | 0 | 1 | Cambridge | P Marsden |
| 08/09/2018 | Cambridge | 1 | 2 | Carlisle | O Yates |
| 15/09/2018 | Colchester | 3 | 0 | Cambridge | L Swabey |
| 22/09/2018 | Cambridge | 1 | 1 | Mansfield | N Kinseley |
| 29/09/2018 | Newport County | 4 | 2 | Cambridge | B Huxtable |
| 02/10/2018 | Cambridge | 1 | 3 | Forest Green | C Breakspear |
| 06/10/2018 | Crawley Town | 2 | 0 | Cambridge | G Ward |
| 13/10/2018 | Cambridge | 0 | 1 | Milton Keynes Dons | D Whitestone |
| 20/10/2018 | Lincoln | 1 | 1 | Cambridge | L Collins |
| 23/10/2018 | Swindon | 0 | 2 | Cambridge | M Donohue |
| 27/10/2018 | Cambridge | 1 | 0 | Macclesfield | C Hicks |
| 03/11/2018 | Cambridge | 1 | 0 | Grimsby | N Kinseley |
| 17/11/2018 | Oldham | 3 | 1 | Cambridge | A Backhouse |
| 24/11/2018 | Cambridge | 2 | 2 | Bury | C Sarginson |
| 27/11/2018 | Crewe | 2 | 0 | Cambridge | T Nield |
| 08/12/2018 | Tranmere | 1 | 0 | Cambridge | O Yates |
| 15/12/2018 | Cambridge | 0 | 0 | Yeovil | P Wright |
| 22/12/2018 | Morecambe | 3 | 0 | Cambridge | E Sarginson |
| 26/12/2018 | Cambridge | 2 | 1 | Crawley Town | N Hair |
| 29/12/2018 | Cambridge | 1 | 2 | Lincoln | C Boyeson |
| 01/01/2019 | Milton Keynes Dons | 6 | 0 | Cambridge | C Breakspear |
| 05/01/2019 | Cambridge | 2 | 0 | Stevenage | T Kettle |
| 12/01/2019 | Notts County | 0 | 1 | Cambridge | J Busby |
| 19/01/2019 | Cambridge | 3 | 2 | Northampton | M Coy |
| 26/01/2019 | Exeter | 1 | 0 | Cambridge | M Salisbury |
| 09/02/2019 | Cambridge | 1 | 0 | Port Vale | S Stockbridge |
| 16/02/2019 | Cambridge | 0 | 0 | Tranmere | B Huxtable |
| 19/02/2019 | Cheltenham | 2 | 0 | Cambridge | P Marsden |
| 23/02/2019 | Yeovil | 1 | 0 | Cambridge | G Salisbury |
| 02/03/2019 | Grimsby | 0 | 2 | Cambridge | S Oldham |
| 09/03/2019 | Cambridge | 1 | 1 | Oldham | K Johnson |
| 12/03/2019 | Cambridge | 0 | 0 | Crewe | C Breakspear |
| 23/03/2019 | Carlisle | 2 | 2 | Cambridge | A Haines |
| 30/03/2019 | Cambridge | 0 | 1 | Colchester | D Drysdale |
| 02/04/2019 | Bury | 0 | 3 | Cambridge | A Coggins |
| 06/04/2019 | Mansfield | 1 | 0 | Cambridge | C Hicks |
| 13/04/2019 | Cambridge | 0 | 3 | Newport County | R Joyce |
| 19/04/2019 | Cambridge | 0 | 0 | Swindon | B Huxtable |
| 22/04/2019 | Forest Green | 2 | 1 | Cambridge | T Bramall |
| 27/04/2019 | Cambridge | 1 | 2 | Morecambe | N Kinseley |
| 04/05/2019 | Macclesfield | 1 | 1 | Cambridge | J Busby |