Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Exeter | 1 | 0 | Cambridge | T Kettle |
| 12/08/2017 | Cambridge | 1 | 2 | Carlisle | T Nield |
| 19/08/2017 | Crawley Town | 0 | 1 | Cambridge | C Breakspear |
| 26/08/2017 | Cambridge | 0 | 0 | Morecambe | G Horwood |
| 02/09/2017 | Cambridge | 1 | 0 | Colchester | N Kinseley |
| 09/09/2017 | Barnet | 3 | 1 | Cambridge | A Coggins |
| 12/09/2017 | Crewe | 0 | 1 | Cambridge | G Salisbury |
| 16/09/2017 | Cambridge | 2 | 1 | Coventry | M Heywood |
| 23/09/2017 | Mansfield | 2 | 1 | Cambridge | B Toner |
| 26/09/2017 | Cambridge | 3 | 0 | Forest Green | R Joyce |
| 30/09/2017 | Swindon | 2 | 0 | Cambridge | A Woolmer |
| 07/10/2017 | Cambridge | 1 | 3 | Wycombe | G Ward |
| 14/10/2017 | Lincoln | 0 | 0 | Cambridge | K Johnson |
| 17/10/2017 | Cambridge | 2 | 1 | Yeovil | A Haines |
| 21/10/2017 | Cambridge | 2 | 1 | Chesterfield | J Busby |
| 28/10/2017 | Grimsby | 0 | 0 | Cambridge | S Stockbridge |
| 11/11/2017 | Cambridge | 0 | 0 | Accrington | G Horwood |
| 18/11/2017 | Luton | 7 | 0 | Cambridge | N Kinseley |
| 21/11/2017 | Cheltenham | 0 | 0 | Cambridge | J Busby |
| 25/11/2017 | Cambridge | 1 | 0 | Stevenage | B Huxtable |
| 09/12/2017 | Port Vale | 2 | 0 | Cambridge | A Coggins |
| 16/12/2017 | Cambridge | 1 | 2 | Newport County | C Sarginson |
| 23/12/2017 | Notts County | 3 | 3 | Cambridge | A Backhouse |
| 26/12/2017 | Cambridge | 1 | 0 | Barnet | G Salisbury |
| 30/12/2017 | Cambridge | 3 | 1 | Crewe | C Hicks |
| 01/01/2018 | Colchester | 0 | 0 | Cambridge | C Breakspear |
| 13/01/2018 | Cambridge | 0 | 0 | Mansfield | T Kettle |
| 20/01/2018 | Forest Green | 5 | 2 | Cambridge | B Toner |
| 30/01/2018 | Coventry | 3 | 1 | Cambridge | T Nield |
| 03/02/2018 | Yeovil | 2 | 0 | Cambridge | D Drysdale |
| 09/02/2018 | Cambridge | 0 | 0 | Lincoln | D England |
| 13/02/2018 | Chesterfield | 2 | 3 | Cambridge | D Handley |
| 17/02/2018 | Cambridge | 3 | 1 | Grimsby | D Whitestone |
| 20/02/2018 | Cambridge | 1 | 0 | Notts County | C Breakspear |
| 24/02/2018 | Accrington | 1 | 0 | Cambridge | R Lewis |
| 03/03/2018 | Cambridge | 1 | 1 | Luton | J Brooks |
| 10/03/2018 | Wycombe | 1 | 1 | Cambridge | N Kinseley |
| 17/03/2018 | Cambridge | 1 | 3 | Swindon | L Swabey |
| 24/03/2018 | Carlisle | 1 | 1 | Cambridge | R Clark |
| 30/03/2018 | Cambridge | 3 | 1 | Crawley Town | C Hicks |
| 07/04/2018 | Cambridge | 2 | 3 | Exeter | M Coy |
| 14/04/2018 | Stevenage | 0 | 2 | Cambridge | T Nield |
| 21/04/2018 | Cambridge | 4 | 3 | Cheltenham | B Huxtable |
| 24/04/2018 | Morecambe | 0 | 0 | Cambridge | R Joyce |
| 28/04/2018 | Newport County | 2 | 1 | Cambridge | G Salisbury |
| 05/05/2018 | Cambridge | 5 | 0 | Port Vale | C Hicks |