Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Cambridge | 3 | 0 | Newport County | D Handley |
| 15/08/2015 | Carlisle | 4 | 4 | Cambridge | R Clark |
| 18/08/2015 | AFC Wimbledon | 1 | 2 | Cambridge | A Woolmer |
| 22/08/2015 | Cambridge | 0 | 3 | Crawley Town | N Miller |
| 29/08/2015 | Barnet | 0 | 0 | Cambridge | N Kinseley |
| 05/09/2015 | Cambridge | 1 | 3 | Luton | G Salisbury |
| 12/09/2015 | Cambridge | 1 | 1 | Leyton Orient | O Langford |
| 19/09/2015 | Hartlepool | 0 | 0 | Cambridge | G Eltringham |
| 26/09/2015 | Cambridge | 1 | 0 | Stevenage | R Joyce |
| 29/09/2015 | Wycombe | 1 | 0 | Cambridge | S Attwell |
| 03/10/2015 | York | 2 | 2 | Cambridge | B Toner |
| 10/10/2015 | Cambridge | 1 | 3 | Portsmouth | S Stockbridge |
| 17/10/2015 | Cambridge | 2 | 1 | Northampton | D England |
| 21/10/2015 | Exeter | 1 | 0 | Cambridge | J Linington |
| 24/10/2015 | Yeovil | 2 | 3 | Cambridge | C Sarginson |
| 30/10/2015 | Cambridge | 1 | 2 | Bristol Rvs | B Malone |
| 14/11/2015 | Oxford | 1 | 0 | Cambridge | K Hill |
| 21/11/2015 | Cambridge | 2 | 3 | Accrington | I Williamson |
| 24/11/2015 | Morecambe | 2 | 4 | Cambridge | B Toner |
| 28/11/2015 | Cambridge | 3 | 1 | Notts County | C Breakspear |
| 12/12/2015 | Plymouth | 1 | 2 | Cambridge | T Robinson |
| 19/12/2015 | Cambridge | 1 | 1 | Mansfield | R Joyce |
| 26/12/2015 | Dag and Red | 0 | 3 | Cambridge | L Collins |
| 28/12/2015 | Cambridge | 2 | 1 | Barnet | D Webb |
| 02/01/2016 | Cambridge | 1 | 4 | AFC Wimbledon | T Harrington |
| 09/01/2016 | Crawley Town | 1 | 0 | Cambridge | L Swabey |
| 16/01/2016 | Luton | 0 | 0 | Cambridge | A Madley |
| 23/01/2016 | Cambridge | 1 | 1 | Hartlepool | K Hill |
| 30/01/2016 | Leyton Orient | 1 | 3 | Cambridge | M Bull |
| 06/02/2016 | Cambridge | 1 | 0 | Dag and Red | C Boyeson |
| 13/02/2016 | Stevenage | 2 | 0 | Cambridge | C Kavanagh |
| 20/02/2016 | Cambridge | 3 | 1 | York | N Kinseley |
| 27/02/2016 | Portsmouth | 2 | 1 | Cambridge | O Langford |
| 01/03/2016 | Cambridge | 1 | 0 | Wycombe | A Davies |
| 05/03/2016 | Cambridge | 0 | 1 | Exeter | F Graham |
| 12/03/2016 | Northampton | 1 | 1 | Cambridge | R Lewis |
| 19/03/2016 | Cambridge | 3 | 0 | Yeovil | L Swabey |
| 25/03/2016 | Bristol Rvs | 3 | 0 | Cambridge | S Martin |
| 28/03/2016 | Cambridge | 0 | 0 | Oxford | M Haywood |
| 02/04/2016 | Accrington | 1 | 1 | Cambridge | N Miller |
| 09/04/2016 | Newport County | 0 | 1 | Cambridge | D England |
| 16/04/2016 | Cambridge | 0 | 0 | Carlisle | B Toner |
| 19/04/2016 | Cambridge | 7 | 0 | Morecambe | J Adcock |
| 23/04/2016 | Notts County | 1 | 2 | Cambridge | R Joyce |
| 30/04/2016 | Cambridge | 2 | 2 | Plymouth | T Kettle |
| 07/05/2016 | Mansfield | 0 | 0 | Cambridge | E Ilderton |