Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | QPR | 4 | 0 | Barnsley | J Linington |
| 14/08/2010 | Barnsley | 1 | 0 | Crystal Palace | N Swarbrick |
| 21/08/2010 | Bristol City | 3 | 3 | Barnsley | A Penn |
| 28/08/2010 | Barnsley | 2 | 0 | Middlesbrough | K Hill |
| 11/09/2010 | Norwich | 2 | 1 | Barnsley | G Ward |
| 14/09/2010 | Barnsley | 5 | 2 | Leeds | S Tanner |
| 18/09/2010 | Barnsley | 1 | 1 | Derby | D Webb |
| 25/09/2010 | Reading | 3 | 0 | Barnsley | P Miller |
| 28/09/2010 | Scunthorpe | 0 | 0 | Barnsley | R Shoebridge |
| 02/10/2010 | Barnsley | 1 | 2 | Cardiff | T Kettle |
| 16/10/2010 | Barnsley | 3 | 1 | Nott'm Forest | P Crossley |
| 19/10/2010 | Burnley | 3 | 0 | Barnsley | A Haines |
| 23/10/2010 | Coventry | 3 | 0 | Barnsley | A Bates |
| 30/10/2010 | Barnsley | 1 | 1 | Hull | A D'Urso |
| 06/11/2010 | Barnsley | 0 | 2 | Leicester | N Swarbrick |
| 09/11/2010 | Preston | 1 | 2 | Barnsley | O Langford |
| 13/11/2010 | Ipswich | 1 | 3 | Barnsley | P Tierney |
| 20/11/2010 | Barnsley | 1 | 0 | Portsmouth | D Foster |
| 27/11/2010 | Barnsley | 0 | 0 | Watford | G Salisbury |
| 11/12/2010 | Barnsley | 1 | 0 | Sheffield United | M Jones |
| 26/12/2010 | Barnsley | 1 | 2 | Burnley | C Webster |
| 28/12/2010 | Swansea | 1 | 0 | Barnsley | G Ward |
| 01/01/2011 | Nott'm Forest | 2 | 2 | Barnsley | D Whitestone |
| 03/01/2011 | Barnsley | 2 | 1 | Coventry | C Boyeson |
| 15/01/2011 | Hull | 2 | 0 | Barnsley | P Quinn |
| 22/01/2011 | Barnsley | 1 | 1 | Swansea | P Gibbs |
| 25/01/2011 | Doncaster | 0 | 2 | Barnsley | M Haywood |
| 28/01/2011 | Millwall | 2 | 0 | Barnsley | G Scott |
| 01/02/2011 | Barnsley | 2 | 0 | Preston | R Booth |
| 05/02/2011 | Leicester | 4 | 1 | Barnsley | K Hill |
| 12/02/2011 | Barnsley | 1 | 1 | Ipswich | D Drysdale |
| 19/02/2011 | Portsmouth | 1 | 0 | Barnsley | R East |
| 22/02/2011 | Leeds | 3 | 3 | Barnsley | M Clattenburg |
| 26/02/2011 | Barnsley | 0 | 2 | Norwich | E Ilderton |
| 05/03/2011 | Derby | 0 | 0 | Barnsley | D Deadman |
| 08/03/2011 | Barnsley | 2 | 1 | Scunthorpe | K Wright |
| 13/03/2011 | Cardiff | 2 | 2 | Barnsley | R Booth |
| 19/03/2011 | Barnsley | 0 | 1 | Reading | S Tanner |
| 02/04/2011 | Crystal Palace | 2 | 1 | Barnsley | K Evans |
| 09/04/2011 | Barnsley | 4 | 2 | Bristol City | N Miller |
| 12/04/2011 | Barnsley | 0 | 1 | QPR | A Bates |
| 16/04/2011 | Middlesbrough | 1 | 1 | Barnsley | C Sarginson |
| 23/04/2011 | Watford | 1 | 0 | Barnsley | D McDermid |
| 25/04/2011 | Barnsley | 2 | 2 | Doncaster | P Walton |
| 30/04/2011 | Sheffield United | 2 | 2 | Barnsley | G Salisbury |
| 07/05/2011 | Barnsley | 1 | 0 | Millwall | M Russell |