Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Accrington | 0 | 0 | Aldershot | J Waugh |
| 14/08/2010 | Northampton | 0 | 0 | Accrington | P Crossley |
| 21/08/2010 | Accrington | 3 | 0 | Macclesfield | C Pawson |
| 28/08/2010 | Oxford | 0 | 0 | Accrington | M Naylor |
| 04/09/2010 | Accrington | 1 | 1 | Wycombe | R Madley |
| 11/09/2010 | Torquay | 0 | 0 | Accrington | S Hooper |
| 17/09/2010 | Accrington | 3 | 0 | Lincoln | A Bates |
| 25/09/2010 | Port Vale | 2 | 0 | Accrington | T Kettle |
| 28/09/2010 | Stockport | 2 | 2 | Accrington | A Haines |
| 02/10/2010 | Accrington | 7 | 4 | Gillingham | I Williamson |
| 09/10/2010 | Bury | 3 | 0 | Accrington | E Ilderton |
| 16/10/2010 | Accrington | 2 | 3 | Rotherham | G Eltringham |
| 23/10/2010 | Hereford | 1 | 1 | Accrington | S Tanner |
| 30/10/2010 | Accrington | 2 | 4 | Cheltenham | R Lewis |
| 02/11/2010 | Chesterfield | 5 | 2 | Accrington | D Whitestone |
| 13/11/2010 | Southend | 1 | 1 | Accrington | G Sutton |
| 20/11/2010 | Accrington | 1 | 0 | Stevenage | P Quinn |
| 23/11/2010 | Bradford | 1 | 1 | Accrington | A Bates |
| 11/12/2010 | Barnet | 2 | 0 | Accrington | A Woolmer |
| 01/01/2011 | Morecambe | 1 | 2 | Accrington | S Mathieson |
| 03/01/2011 | Accrington | 2 | 2 | Chesterfield | M Haywood |
| 08/01/2011 | Accrington | 1 | 0 | Bury | K Evans |
| 15/01/2011 | Cheltenham | 1 | 2 | Accrington | M Russell |
| 18/01/2011 | Accrington | 1 | 3 | Shrewsbury | C Sarginson |
| 01/02/2011 | Accrington | 1 | 1 | Morecambe | J Moss |
| 05/02/2011 | Stevenage | 2 | 2 | Accrington | A D'Urso |
| 15/02/2011 | Rotherham | 2 | 0 | Accrington | M Brown |
| 19/02/2011 | Wycombe | 1 | 2 | Accrington | B Malone |
| 22/02/2011 | Accrington | 3 | 2 | Crewe | P Tierney |
| 26/02/2011 | Accrington | 1 | 0 | Torquay | M Russell |
| 05/03/2011 | Lincoln | 0 | 0 | Accrington | G Horwood |
| 08/03/2011 | Accrington | 3 | 0 | Stockport | O Langford |
| 12/03/2011 | Gillingham | 3 | 1 | Accrington | D Phillips |
| 15/03/2011 | Accrington | 3 | 1 | Burton | E Ilderton |
| 19/03/2011 | Accrington | 3 | 0 | Port Vale | D Foster |
| 22/03/2011 | Crewe | 0 | 0 | Accrington | D Coote |
| 26/03/2011 | Aldershot | 1 | 1 | Accrington | P Crossley |
| 30/03/2011 | Accrington | 4 | 0 | Hereford | P Quinn |
| 02/04/2011 | Accrington | 3 | 1 | Northampton | P Gibbs |
| 05/04/2011 | Accrington | 3 | 1 | Southend | D Webb |
| 08/04/2011 | Macclesfield | 2 | 2 | Accrington | S Rushton |
| 16/04/2011 | Accrington | 0 | 0 | Oxford | C Webster |
| 23/04/2011 | Accrington | 3 | 0 | Bradford | M Naylor |
| 25/04/2011 | Shrewsbury | 0 | 0 | Accrington | D Coote |
| 30/04/2011 | Accrington | 3 | 1 | Barnet | C Boyeson |
| 07/05/2011 | Burton | 1 | 1 | Accrington | M Haywood |