Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Wigan | 3 | 2 | Sheffield Weds | T Robinson |
| 11/08/2018 | Aston Villa | 3 | 2 | Wigan | J Simpson |
| 18/08/2018 | Wigan | 2 | 2 | Nott'm Forest | G Eltringham |
| 22/08/2018 | Stoke | 0 | 3 | Wigan | J Brooks |
| 25/08/2018 | QPR | 1 | 0 | Wigan | S Martin |
| 01/09/2018 | Wigan | 1 | 0 | Rotherham | S Duncan |
| 15/09/2018 | Brentford | 2 | 0 | Wigan | D England |
| 18/09/2018 | Wigan | 2 | 1 | Hull | D Webb |
| 21/09/2018 | Wigan | 1 | 0 | Bristol City | O Langford |
| 29/09/2018 | Norwich | 1 | 0 | Wigan | G Ward |
| 02/10/2018 | Wigan | 0 | 0 | Swansea | J Brooks |
| 06/10/2018 | Preston | 4 | 0 | Wigan | L Probert |
| 20/10/2018 | Wigan | 1 | 0 | West Brom | J Simpson |
| 23/10/2018 | Millwall | 2 | 1 | Wigan | J Linington |
| 27/10/2018 | Sheffield United | 4 | 2 | Wigan | T Harrington |
| 04/11/2018 | Wigan | 1 | 2 | Leeds | A Davies |
| 10/11/2018 | Middlesbrough | 2 | 0 | Wigan | D England |
| 24/11/2018 | Wigan | 0 | 0 | Reading | O Langford |
| 28/11/2018 | Wigan | 3 | 1 | Blackburn | K Stroud |
| 01/12/2018 | Bolton | 1 | 1 | Wigan | S Hooper |
| 08/12/2018 | Wigan | 0 | 1 | Derby | G Ward |
| 15/12/2018 | Ipswich | 1 | 0 | Wigan | S Duncan |
| 22/12/2018 | Wigan | 0 | 3 | Birmingham | R Joyce |
| 26/12/2018 | West Brom | 2 | 0 | Wigan | R Jones |
| 29/12/2018 | Swansea | 2 | 2 | Wigan | J Linington |
| 01/01/2019 | Wigan | 0 | 3 | Sheffield United | A Madley |
| 12/01/2019 | Wigan | 3 | 0 | Aston Villa | T Harrington |
| 19/01/2019 | Sheffield Weds | 1 | 0 | Wigan | P Bankes |
| 26/01/2019 | Nott'm Forest | 3 | 1 | Wigan | A Davies |
| 02/02/2019 | Wigan | 2 | 1 | QPR | S Duncan |
| 09/02/2019 | Rotherham | 1 | 1 | Wigan | O Langford |
| 13/02/2019 | Wigan | 0 | 0 | Stoke | K Stroud |
| 23/02/2019 | Wigan | 1 | 1 | Ipswich | L Probert |
| 02/03/2019 | Wigan | 0 | 0 | Middlesbrough | S Martin |
| 05/03/2019 | Derby | 2 | 1 | Wigan | T Harrington |
| 09/03/2019 | Reading | 3 | 2 | Wigan | A Davies |
| 12/03/2019 | Blackburn | 3 | 0 | Wigan | C Kavanagh |
| 16/03/2019 | Wigan | 5 | 2 | Bolton | R Jones |
| 30/03/2019 | Wigan | 0 | 0 | Brentford | A Woolmer |
| 06/04/2019 | Bristol City | 2 | 2 | Wigan | K Stroud |
| 10/04/2019 | Hull | 2 | 1 | Wigan | D Webb |
| 14/04/2019 | Wigan | 1 | 1 | Norwich | J Linington |
| 19/04/2019 | Leeds | 1 | 2 | Wigan | S Duncan |
| 22/04/2019 | Wigan | 2 | 0 | Preston | A Madley |
| 27/04/2019 | Birmingham | 1 | 1 | Wigan | S Martin |
| 05/05/2019 | Wigan | 1 | 0 | Millwall | A Woolmer |