Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2018 | Leeds | 3 | 1 | Stoke | S Duncan |
| 11/08/2018 | Stoke | 1 | 1 | Brentford | A Davies |
| 18/08/2018 | Preston | 2 | 2 | Stoke | A Madley |
| 22/08/2018 | Stoke | 0 | 3 | Wigan | J Brooks |
| 25/08/2018 | Stoke | 2 | 0 | Hull | D Bond |
| 01/09/2018 | West Brom | 2 | 1 | Stoke | S Hooper |
| 15/09/2018 | Sheffield Weds | 2 | 2 | Stoke | G Eltringham |
| 18/09/2018 | Stoke | 1 | 0 | Swansea | P Tierney |
| 22/09/2018 | Stoke | 2 | 3 | Blackburn | T Harrington |
| 29/09/2018 | Rotherham | 2 | 2 | Stoke | D Webb |
| 02/10/2018 | Stoke | 2 | 0 | Bolton | J Simpson |
| 06/10/2018 | Norwich | 0 | 1 | Stoke | D Coote |
| 20/10/2018 | Stoke | 0 | 1 | Birmingham | R East |
| 23/10/2018 | Sheffield United | 1 | 1 | Stoke | G Ward |
| 27/10/2018 | Bristol City | 0 | 1 | Stoke | A Madley |
| 03/11/2018 | Stoke | 0 | 0 | Middlesbrough | R Jones |
| 10/11/2018 | Nott'm Forest | 0 | 0 | Stoke | O Langford |
| 24/11/2018 | Stoke | 2 | 2 | QPR | A Davies |
| 28/11/2018 | Stoke | 2 | 1 | Derby | D England |
| 01/12/2018 | Reading | 2 | 2 | Stoke | D Coote |
| 08/12/2018 | Stoke | 2 | 0 | Ipswich | G Eltringham |
| 15/12/2018 | Aston Villa | 2 | 2 | Stoke | P Bankes |
| 22/12/2018 | Stoke | 1 | 0 | Millwall | C Kavanagh |
| 26/12/2018 | Birmingham | 2 | 0 | Stoke | D Bond |
| 29/12/2018 | Bolton | 0 | 0 | Stoke | K Stroud |
| 01/01/2019 | Stoke | 0 | 2 | Bristol City | P Tierney |
| 12/01/2019 | Brentford | 3 | 1 | Stoke | T Robinson |
| 19/01/2019 | Stoke | 2 | 1 | Leeds | G Ward |
| 26/01/2019 | Stoke | 0 | 2 | Preston | O Langford |
| 02/02/2019 | Hull | 2 | 0 | Stoke | P Bankes |
| 09/02/2019 | Stoke | 0 | 1 | West Brom | J Simpson |
| 13/02/2019 | Wigan | 0 | 0 | Stoke | K Stroud |
| 16/02/2019 | Ipswich | 1 | 1 | Stoke | S Duncan |
| 23/02/2019 | Stoke | 1 | 1 | Aston Villa | D Webb |
| 02/03/2019 | Stoke | 2 | 0 | Nott'm Forest | R East |
| 09/03/2019 | QPR | 0 | 0 | Stoke | G Ward |
| 13/03/2019 | Derby | 0 | 0 | Stoke | O Langford |
| 16/03/2019 | Stoke | 0 | 0 | Reading | J Simpson |
| 30/03/2019 | Stoke | 0 | 0 | Sheffield Weds | A Madley |
| 06/04/2019 | Blackburn | 0 | 1 | Stoke | G Eltringham |
| 09/04/2019 | Swansea | 3 | 1 | Stoke | J Linington |
| 13/04/2019 | Stoke | 2 | 2 | Rotherham | A Woolmer |
| 19/04/2019 | Middlesbrough | 1 | 0 | Stoke | D Bond |
| 22/04/2019 | Stoke | 2 | 2 | Norwich | T Harrington |
| 27/04/2019 | Millwall | 0 | 0 | Stoke | O Langford |
| 05/05/2019 | Stoke | 2 | 2 | Sheffield United | G Eltringham |