Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Preston | 1 | 0 | QPR | D England |
| 11/08/2018 | Swansea | 1 | 0 | Preston | J Linington |
| 18/08/2018 | Preston | 2 | 2 | Stoke | A Madley |
| 22/08/2018 | Norwich | 2 | 0 | Preston | G Ward |
| 25/08/2018 | Derby | 2 | 0 | Preston | D Webb |
| 01/09/2018 | Preston | 2 | 2 | Bolton | A Davies |
| 15/09/2018 | Preston | 2 | 3 | Reading | D Bond |
| 18/09/2018 | Leeds | 3 | 0 | Preston | G Eltringham |
| 22/09/2018 | Sheffield United | 3 | 2 | Preston | S Duncan |
| 29/09/2018 | Preston | 2 | 3 | West Brom | T Harrington |
| 02/10/2018 | Aston Villa | 3 | 3 | Preston | P Bankes |
| 06/10/2018 | Preston | 4 | 0 | Wigan | L Probert |
| 20/10/2018 | Hull | 1 | 1 | Preston | G Ward |
| 24/10/2018 | Preston | 4 | 3 | Brentford | S Duncan |
| 27/10/2018 | Preston | 1 | 1 | Rotherham | J Simpson |
| 03/11/2018 | Ipswich | 1 | 1 | Preston | A Woolmer |
| 10/11/2018 | Bristol City | 0 | 1 | Preston | G Eltringham |
| 24/11/2018 | Preston | 4 | 1 | Blackburn | A Madley |
| 27/11/2018 | Preston | 1 | 1 | Middlesbrough | P Bankes |
| 01/12/2018 | Birmingham | 3 | 0 | Preston | D Webb |
| 08/12/2018 | Nott'm Forest | 0 | 1 | Preston | S Martin |
| 15/12/2018 | Preston | 3 | 2 | Millwall | J Duncan |
| 22/12/2018 | Sheffield Weds | 1 | 0 | Preston | D Coote |
| 26/12/2018 | Preston | 1 | 2 | Hull | S Duncan |
| 29/12/2018 | Preston | 1 | 1 | Aston Villa | G Eltringham |
| 01/01/2019 | Rotherham | 2 | 1 | Preston | L Probert |
| 12/01/2019 | Preston | 1 | 1 | Swansea | K Stroud |
| 19/01/2019 | QPR | 1 | 4 | Preston | A Madley |
| 26/01/2019 | Stoke | 0 | 2 | Preston | O Langford |
| 01/02/2019 | Preston | 0 | 0 | Derby | D Bond |
| 09/02/2019 | Bolton | 1 | 2 | Preston | A Madley |
| 13/02/2019 | Preston | 3 | 1 | Norwich | G Eltringham |
| 16/02/2019 | Preston | 0 | 0 | Nott'm Forest | T Robinson |
| 23/02/2019 | Millwall | 1 | 3 | Preston | S Martin |
| 02/03/2019 | Preston | 1 | 1 | Bristol City | J Simpson |
| 09/03/2019 | Blackburn | 0 | 1 | Preston | O Langford |
| 13/03/2019 | Middlesbrough | 1 | 2 | Preston | K Stroud |
| 16/03/2019 | Preston | 1 | 0 | Birmingham | S Duncan |
| 30/03/2019 | Reading | 2 | 1 | Preston | T Harrington |
| 06/04/2019 | Preston | 0 | 1 | Sheffield United | G Ward |
| 09/04/2019 | Preston | 0 | 2 | Leeds | R Jones |
| 13/04/2019 | West Brom | 4 | 1 | Preston | R East |
| 19/04/2019 | Preston | 4 | 0 | Ipswich | S Martin |
| 22/04/2019 | Wigan | 2 | 0 | Preston | A Madley |
| 27/04/2019 | Preston | 3 | 3 | Sheffield Weds | J Simpson |
| 05/05/2019 | Brentford | 3 | 0 | Preston | J Linington |