Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Barnsley | 4 | 0 | Oxford | R Joyce |
| 11/08/2018 | Oxford | 0 | 2 | Fleetwood Town | O Yates |
| 18/08/2018 | Portsmouth | 4 | 1 | Oxford | L Swabey |
| 21/08/2018 | Oxford | 2 | 3 | Accrington | G Eltringham |
| 25/08/2018 | Oxford | 3 | 1 | Burton | T Kettle |
| 01/09/2018 | Sunderland | 1 | 1 | Oxford | M Heywood |
| 09/09/2018 | Oxford | 1 | 2 | Coventry | D Whitestone |
| 15/09/2018 | Wycombe | 0 | 0 | Oxford | D Webb |
| 22/09/2018 | Oxford | 1 | 2 | Walsall | A Young |
| 29/09/2018 | AFC Wimbledon | 2 | 1 | Oxford | R Lewis |
| 02/10/2018 | Oxford | 1 | 2 | Luton | M Salisbury |
| 06/10/2018 | Southend | 0 | 0 | Oxford | C Hicks |
| 13/10/2018 | Oxford | 2 | 0 | Plymouth | A Woolmer |
| 20/10/2018 | Bristol Rvs | 0 | 0 | Oxford | T Nield |
| 23/10/2018 | Charlton | 1 | 1 | Oxford | D Whitestone |
| 27/10/2018 | Oxford | 3 | 0 | Shrewsbury | M Coy |
| 03/11/2018 | Scunthorpe | 3 | 3 | Oxford | P Marsden |
| 17/11/2018 | Oxford | 1 | 0 | Gillingham | N Hair |
| 24/11/2018 | Bradford | 2 | 0 | Oxford | D Drysdale |
| 27/11/2018 | Oxford | 4 | 2 | Rochdale | C Hicks |
| 08/12/2018 | Peterboro | 2 | 2 | Oxford | C Breakspear |
| 15/12/2018 | Oxford | 2 | 0 | Blackpool | M Donohue |
| 22/12/2018 | Doncaster | 2 | 2 | Oxford | A Young |
| 26/12/2018 | Oxford | 0 | 1 | Southend | T Robinson |
| 29/12/2018 | Oxford | 0 | 2 | Bristol Rvs | G Salisbury |
| 01/01/2019 | Plymouth | 3 | 0 | Oxford | B Huxtable |
| 12/01/2019 | Fleetwood Town | 2 | 2 | Oxford | A Haines |
| 19/01/2019 | Oxford | 2 | 1 | Portsmouth | C Sarginson |
| 29/01/2019 | Oxford | 2 | 2 | Barnsley | K Johnson |
| 02/02/2019 | Burton | 0 | 0 | Oxford | B Huxtable |
| 09/02/2019 | Oxford | 1 | 1 | Sunderland | S Oldham |
| 16/02/2019 | Oxford | 0 | 1 | Peterboro | R Joyce |
| 19/02/2019 | Accrington | 4 | 2 | Oxford | C Sarginson |
| 23/02/2019 | Blackpool | 0 | 1 | Oxford | A Haines |
| 02/03/2019 | Oxford | 2 | 1 | Scunthorpe | M Salisbury |
| 09/03/2019 | Gillingham | 1 | 0 | Oxford | O Yates |
| 12/03/2019 | Rochdale | 0 | 0 | Oxford | A Backhouse |
| 16/03/2019 | Oxford | 1 | 0 | Bradford | A Davies |
| 23/03/2019 | Coventry | 0 | 1 | Oxford | S Oldham |
| 30/03/2019 | Oxford | 2 | 1 | Wycombe | S Hooper |
| 06/04/2019 | Walsall | 1 | 3 | Oxford | D Webb |
| 13/04/2019 | Oxford | 0 | 0 | AFC Wimbledon | A Young |
| 19/04/2019 | Oxford | 2 | 1 | Charlton | D Drysdale |
| 22/04/2019 | Shrewsbury | 2 | 3 | Oxford | C Sarginson |
| 27/04/2019 | Oxford | 2 | 2 | Doncaster | C Breakspear |
| 04/05/2019 | Luton | 3 | 1 | Oxford | M Salisbury |