Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Northampton | 0 | 1 | Lincoln | L Swabey |
| 11/08/2018 | Carlisle | 2 | 2 | Northampton | T Nield |
| 18/08/2018 | Northampton | 2 | 2 | Cambridge | S Stockbridge |
| 21/08/2018 | Morecambe | 1 | 0 | Northampton | M Heywood |
| 25/08/2018 | Colchester | 1 | 2 | Northampton | A Young |
| 01/09/2018 | Northampton | 1 | 1 | Tranmere | N Kinseley |
| 08/09/2018 | Northampton | 1 | 3 | Cheltenham | L Collins |
| 15/09/2018 | Port Vale | 2 | 0 | Northampton | T Bramall |
| 22/09/2018 | Northampton | 0 | 0 | Notts County | P Marsden |
| 29/09/2018 | Mansfield | 4 | 0 | Northampton | T Kettle |
| 02/10/2018 | Northampton | 0 | 0 | Bury | C Sarginson |
| 06/10/2018 | Swindon | 1 | 1 | Northampton | N Hair |
| 13/10/2018 | Northampton | 2 | 1 | Forest Green | O Yates |
| 20/10/2018 | Milton Keynes Dons | 1 | 0 | Northampton | B Huxtable |
| 23/10/2018 | Macclesfield | 0 | 5 | Northampton | S Stockbridge |
| 27/10/2018 | Northampton | 2 | 1 | Oldham | C Breakspear |
| 03/11/2018 | Northampton | 2 | 0 | Crewe | S Oldham |
| 17/11/2018 | Exeter | 2 | 2 | Northampton | P Wright |
| 24/11/2018 | Northampton | 2 | 2 | Grimsby | T Kettle |
| 27/11/2018 | Newport County | 3 | 1 | Northampton | A Davies |
| 08/12/2018 | Crawley Town | 0 | 1 | Northampton | C Hicks |
| 15/12/2018 | Northampton | 1 | 1 | Stevenage | C Sarginson |
| 22/12/2018 | Yeovil | 1 | 1 | Northampton | R Lewis |
| 26/12/2018 | Northampton | 1 | 1 | Swindon | A Coggins |
| 29/12/2018 | Northampton | 2 | 2 | Milton Keynes Dons | G Scott |
| 01/01/2019 | Forest Green | 2 | 1 | Northampton | K Johnson |
| 12/01/2019 | Northampton | 3 | 0 | Carlisle | L Swabey |
| 19/01/2019 | Cambridge | 3 | 2 | Northampton | M Coy |
| 26/01/2019 | Northampton | 1 | 1 | Morecambe | L Collins |
| 02/02/2019 | Northampton | 0 | 4 | Colchester | R Joyce |
| 05/02/2019 | Tranmere | 1 | 2 | Northampton | P Marsden |
| 09/02/2019 | Lincoln | 1 | 1 | Northampton | M Salisbury |
| 16/02/2019 | Northampton | 0 | 0 | Crawley Town | N Kinseley |
| 23/02/2019 | Stevenage | 1 | 2 | Northampton | L Swabey |
| 02/03/2019 | Crewe | 0 | 2 | Northampton | L Collins |
| 09/03/2019 | Northampton | 2 | 1 | Exeter | A Haines |
| 12/03/2019 | Northampton | 1 | 0 | Newport County | A Coggins |
| 16/03/2019 | Grimsby | 0 | 0 | Northampton | O Yates |
| 23/03/2019 | Cheltenham | 3 | 1 | Northampton | C Breakspear |
| 30/03/2019 | Northampton | 1 | 2 | Port Vale | N Hair |
| 06/04/2019 | Notts County | 2 | 2 | Northampton | B Toner |
| 13/04/2019 | Northampton | 1 | 1 | Mansfield | P Marsden |
| 19/04/2019 | Northampton | 3 | 1 | Macclesfield | K Johnson |
| 22/04/2019 | Bury | 3 | 1 | Northampton | M Salisbury |
| 27/04/2019 | Northampton | 2 | 2 | Yeovil | A Backhouse |
| 04/05/2019 | Oldham | 2 | 5 | Northampton | T Bramall |