Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Portsmouth | 1 | 0 | Luton | G Ward |
| 11/08/2018 | Luton | 1 | 1 | Sunderland | C Breakspear |
| 18/08/2018 | Peterboro | 3 | 1 | Luton | G Salisbury |
| 21/08/2018 | Luton | 2 | 0 | Southend | T Kettle |
| 25/08/2018 | Luton | 3 | 2 | Shrewsbury | C Boyeson |
| 01/09/2018 | Wycombe | 1 | 1 | Luton | D England |
| 08/09/2018 | Doncaster | 2 | 1 | Luton | T Nield |
| 15/09/2018 | Luton | 1 | 0 | Bristol Rvs | R Lewis |
| 22/09/2018 | Blackpool | 0 | 0 | Luton | S Stockbridge |
| 29/09/2018 | Luton | 2 | 2 | Charlton | A Coggins |
| 02/10/2018 | Oxford | 1 | 2 | Luton | M Salisbury |
| 06/10/2018 | Luton | 3 | 2 | Scunthorpe | K Johnson |
| 13/10/2018 | Barnsley | 3 | 2 | Luton | R Joyce |
| 20/10/2018 | Luton | 2 | 0 | Walsall | A Woolmer |
| 23/10/2018 | Luton | 4 | 1 | Accrington | C Sarginson |
| 27/10/2018 | AFC Wimbledon | 0 | 2 | Luton | A Davies |
| 03/11/2018 | Rochdale | 0 | 0 | Luton | O Yates |
| 17/11/2018 | Luton | 5 | 1 | Plymouth | D England |
| 24/11/2018 | Gillingham | 1 | 3 | Luton | K Johnson |
| 27/11/2018 | Luton | 4 | 0 | Bradford | A Coggins |
| 08/12/2018 | Luton | 2 | 0 | Fleetwood Town | N Kinseley |
| 15/12/2018 | Coventry | 1 | 2 | Luton | C Breakspear |
| 22/12/2018 | Luton | 2 | 0 | Burton | C Hicks |
| 26/12/2018 | Scunthorpe | 0 | 2 | Luton | M Coy |
| 29/12/2018 | Walsall | 2 | 2 | Luton | O Yates |
| 01/01/2019 | Luton | 0 | 0 | Barnsley | J Brooks |
| 12/01/2019 | Sunderland | 1 | 1 | Luton | L Probert |
| 19/01/2019 | Luton | 4 | 0 | Peterboro | D Coote |
| 26/01/2019 | Southend | 0 | 1 | Luton | T Bramall |
| 29/01/2019 | Luton | 3 | 2 | Portsmouth | S Hooper |
| 02/02/2019 | Shrewsbury | 0 | 3 | Luton | G Salisbury |
| 09/02/2019 | Luton | 3 | 0 | Wycombe | A Davies |
| 16/02/2019 | Fleetwood Town | 1 | 2 | Luton | P Bankes |
| 24/02/2019 | Luton | 1 | 1 | Coventry | R Joyce |
| 02/03/2019 | Luton | 2 | 0 | Rochdale | L Swabey |
| 09/03/2019 | Plymouth | 0 | 0 | Luton | D Drysdale |
| 12/03/2019 | Bradford | 0 | 1 | Luton | M Salisbury |
| 16/03/2019 | Luton | 2 | 2 | Gillingham | A Haines |
| 23/03/2019 | Luton | 4 | 0 | Doncaster | J Busby |
| 30/03/2019 | Bristol Rvs | 1 | 2 | Luton | C Breakspear |
| 06/04/2019 | Luton | 2 | 2 | Blackpool | L Collins |
| 13/04/2019 | Charlton | 3 | 1 | Luton | G Ward |
| 20/04/2019 | Accrington | 0 | 3 | Luton | C Boyeson |
| 23/04/2019 | Luton | 2 | 2 | AFC Wimbledon | B Toner |
| 27/04/2019 | Burton | 2 | 1 | Luton | P Wright |
| 04/05/2019 | Luton | 3 | 1 | Oxford | M Salisbury |