Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Preston | 1 | 0 | Sheffield Weds | T Harrington |
| 12/08/2017 | Leeds | 0 | 0 | Preston | S Duncan |
| 15/08/2017 | Derby | 1 | 0 | Preston | G Eltringham |
| 19/08/2017 | Preston | 1 | 0 | Reading | A Madley |
| 26/08/2017 | Middlesbrough | 0 | 0 | Preston | D England |
| 09/09/2017 | Preston | 1 | 1 | Barnsley | P Bankes |
| 12/09/2017 | Preston | 3 | 0 | Cardiff | O Langford |
| 16/09/2017 | Birmingham | 1 | 3 | Preston | K Stroud |
| 23/09/2017 | Preston | 0 | 0 | Millwall | D Bond |
| 26/09/2017 | Hull | 1 | 2 | Preston | J Linington |
| 30/09/2017 | Preston | 2 | 2 | Sunderland | C Kavanagh |
| 14/10/2017 | Fulham | 2 | 2 | Preston | D England |
| 21/10/2017 | Wolves | 3 | 2 | Preston | S Martin |
| 28/10/2017 | Preston | 2 | 3 | Brentford | D Coote |
| 01/11/2017 | Preston | 0 | 2 | Aston Villa | P Bankes |
| 04/11/2017 | Ipswich | 3 | 0 | Preston | A Madley |
| 17/11/2017 | Preston | 0 | 0 | Bolton | S Hooper |
| 21/11/2017 | Bristol City | 1 | 2 | Preston | D Bond |
| 25/11/2017 | Norwich | 1 | 1 | Preston | T Robinson |
| 02/12/2017 | Preston | 1 | 0 | QPR | J Simpson |
| 09/12/2017 | Burton | 1 | 2 | Preston | K Stroud |
| 16/12/2017 | Preston | 1 | 0 | Sheffield United | T Robinson |
| 23/12/2017 | Preston | 1 | 1 | Nott'm Forest | S Duncan |
| 26/12/2017 | Barnsley | 0 | 0 | Preston | G Eltringham |
| 29/12/2017 | Cardiff | 0 | 1 | Preston | J Linington |
| 01/01/2018 | Preston | 2 | 3 | Middlesbrough | D Coote |
| 13/01/2018 | Millwall | 1 | 1 | Preston | J Simpson |
| 20/01/2018 | Preston | 1 | 1 | Birmingham | A Davies |
| 30/01/2018 | Nott'm Forest | 0 | 3 | Preston | G Eltringham |
| 03/02/2018 | Preston | 2 | 1 | Hull | S Martin |
| 10/02/2018 | Brentford | 1 | 1 | Preston | S Hooper |
| 17/02/2018 | Preston | 1 | 1 | Wolves | R Jones |
| 20/02/2018 | Aston Villa | 1 | 1 | Preston | D England |
| 24/02/2018 | Preston | 0 | 1 | Ipswich | S Duncan |
| 03/03/2018 | Bolton | 1 | 3 | Preston | P Bankes |
| 06/03/2018 | Preston | 2 | 1 | Bristol City | G Eltringham |
| 10/03/2018 | Preston | 1 | 2 | Fulham | S Hooper |
| 17/03/2018 | Sunderland | 0 | 2 | Preston | D Bond |
| 30/03/2018 | Sheffield Weds | 4 | 1 | Preston | T Robinson |
| 02/04/2018 | Preston | 0 | 1 | Derby | T Harrington |
| 07/04/2018 | Reading | 1 | 0 | Preston | A Madley |
| 10/04/2018 | Preston | 3 | 1 | Leeds | L Probert |
| 14/04/2018 | QPR | 1 | 2 | Preston | R Jones |
| 21/04/2018 | Preston | 0 | 0 | Norwich | G Eltringham |
| 28/04/2018 | Sheffield United | 0 | 1 | Preston | J Linington |
| 06/05/2018 | Preston | 2 | 1 | Burton | A Madley |