Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Portsmouth | 2 | 0 | Rochdale | L Probert |
| 12/08/2017 | Oxford | 3 | 0 | Portsmouth | G Salisbury |
| 19/08/2017 | Portsmouth | 1 | 1 | Walsall | B Huxtable |
| 26/08/2017 | Wigan | 1 | 1 | Portsmouth | R Jones |
| 03/09/2017 | Portsmouth | 0 | 1 | Rotherham | G Ward |
| 09/09/2017 | AFC Wimbledon | 0 | 2 | Portsmouth | K Johnson |
| 12/09/2017 | Northampton | 3 | 1 | Portsmouth | D Drysdale |
| 16/09/2017 | Portsmouth | 4 | 1 | Fleetwood Town | D Whitestone |
| 23/09/2017 | Scunthorpe | 2 | 0 | Portsmouth | A Backhouse |
| 26/09/2017 | Portsmouth | 3 | 0 | Bristol Rvs | J Busby |
| 30/09/2017 | Portsmouth | 1 | 2 | Oldham | C Hicks |
| 08/10/2017 | Gillingham | 0 | 1 | Portsmouth | C Sarginson |
| 14/10/2017 | Portsmouth | 2 | 0 | Milton Keynes Dons | G Horwood |
| 17/10/2017 | Doncaster | 2 | 1 | Portsmouth | M Coy |
| 21/10/2017 | Blackburn | 3 | 0 | Portsmouth | C Kavanagh |
| 28/10/2017 | Portsmouth | 0 | 1 | Bradford | D Whitestone |
| 11/11/2017 | Blackpool | 2 | 3 | Portsmouth | J Moss |
| 18/11/2017 | Portsmouth | 1 | 0 | Southend | C Boyeson |
| 21/11/2017 | Peterboro | 2 | 1 | Portsmouth | C Hicks |
| 25/11/2017 | Portsmouth | 1 | 0 | Plymouth | R Madley |
| 09/12/2017 | Charlton | 0 | 1 | Portsmouth | A Madley |
| 16/12/2017 | Portsmouth | 1 | 0 | Bury | J Brooks |
| 23/12/2017 | Shrewsbury | 2 | 0 | Portsmouth | D Handley |
| 26/12/2017 | Portsmouth | 2 | 1 | AFC Wimbledon | L Collins |
| 30/12/2017 | Portsmouth | 3 | 1 | Northampton | L Swabey |
| 01/01/2018 | Bristol Rvs | 2 | 1 | Portsmouth | D Webb |
| 13/01/2018 | Portsmouth | 1 | 1 | Scunthorpe | C Breakspear |
| 20/01/2018 | Rotherham | 1 | 0 | Portsmouth | R Jones |
| 27/01/2018 | Portsmouth | 0 | 1 | Shrewsbury | D Coote |
| 03/02/2018 | Portsmouth | 2 | 2 | Doncaster | G Salisbury |
| 10/02/2018 | Milton Keynes Dons | 1 | 2 | Portsmouth | J Brooks |
| 13/02/2018 | Portsmouth | 1 | 2 | Blackburn | O Langford |
| 17/02/2018 | Southend | 3 | 1 | Portsmouth | L Probert |
| 20/02/2018 | Fleetwood Town | 1 | 2 | Portsmouth | D Webb |
| 24/02/2018 | Portsmouth | 0 | 2 | Blackpool | G Ward |
| 10/03/2018 | Portsmouth | 1 | 3 | Gillingham | C Boyeson |
| 17/03/2018 | Oldham | 0 | 2 | Portsmouth | S Stockbridge |
| 25/03/2018 | Portsmouth | 3 | 0 | Oxford | C Breakspear |
| 31/03/2018 | Walsall | 0 | 1 | Portsmouth | D Handley |
| 02/04/2018 | Portsmouth | 2 | 1 | Wigan | T Robinson |
| 07/04/2018 | Rochdale | 3 | 3 | Portsmouth | A Haines |
| 14/04/2018 | Plymouth | 0 | 0 | Portsmouth | D Whitestone |
| 17/04/2018 | Bradford | 3 | 1 | Portsmouth | A Woolmer |
| 21/04/2018 | Portsmouth | 0 | 1 | Charlton | M Heywood |
| 28/04/2018 | Bury | 1 | 0 | Portsmouth | A Haines |
| 05/05/2018 | Portsmouth | 2 | 0 | Peterboro | J Busby |