Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Oldham | 0 | 2 | Oxford | D Webb |
| 12/08/2017 | Oxford | 3 | 0 | Portsmouth | G Salisbury |
| 19/08/2017 | Scunthorpe | 1 | 0 | Oxford | D Handley |
| 26/08/2017 | Oxford | 1 | 1 | Shrewsbury | N Kinseley |
| 02/09/2017 | Milton Keynes Dons | 1 | 1 | Oxford | D Whitestone |
| 09/09/2017 | Oxford | 3 | 0 | Gillingham | M Salisbury |
| 12/09/2017 | Oxford | 2 | 2 | Bradford | C Sarginson |
| 16/09/2017 | Blackpool | 3 | 1 | Oxford | D Handley |
| 23/09/2017 | Oxford | 1 | 2 | Walsall | S Oldham |
| 26/09/2017 | Bury | 3 | 0 | Oxford | B Toner |
| 30/09/2017 | Peterboro | 1 | 4 | Oxford | T Nield |
| 07/10/2017 | Oxford | 3 | 0 | AFC Wimbledon | D Drysdale |
| 14/10/2017 | Bristol Rvs | 0 | 1 | Oxford | R Joyce |
| 17/10/2017 | Oxford | 1 | 1 | Charlton | C Breakspear |
| 21/10/2017 | Oxford | 3 | 3 | Rotherham | S Stockbridge |
| 28/10/2017 | Fleetwood Town | 2 | 0 | Oxford | T Kettle |
| 11/11/2017 | Oxford | 1 | 2 | Northampton | K Johnson |
| 18/11/2017 | Plymouth | 0 | 4 | Oxford | G Horwood |
| 21/11/2017 | Oxford | 2 | 4 | Blackburn | J Brooks |
| 25/11/2017 | Southend | 1 | 1 | Oxford | D Whitestone |
| 09/12/2017 | Oxford | 1 | 0 | Doncaster | S Stockbridge |
| 16/12/2017 | Rochdale | 0 | 0 | Oxford | C Boyeson |
| 23/12/2017 | Oxford | 0 | 7 | Wigan | R Lewis |
| 26/12/2017 | Gillingham | 1 | 1 | Oxford | N Kinseley |
| 30/12/2017 | Bradford | 3 | 2 | Oxford | E Ilderton |
| 01/01/2018 | Oxford | 3 | 1 | Milton Keynes Dons | A Woolmer |
| 06/01/2018 | Oxford | 1 | 0 | Blackpool | K Johnson |
| 13/01/2018 | Walsall | 2 | 1 | Oxford | B Huxtable |
| 20/01/2018 | Oxford | 1 | 2 | Bury | R Lewis |
| 03/02/2018 | Charlton | 2 | 3 | Oxford | K Stroud |
| 10/02/2018 | Oxford | 1 | 2 | Bristol Rvs | G Ward |
| 13/02/2018 | Rotherham | 3 | 1 | Oxford | E Ilderton |
| 17/02/2018 | Oxford | 0 | 1 | Plymouth | M Heywood |
| 24/02/2018 | Northampton | 0 | 0 | Oxford | M Coy |
| 10/03/2018 | AFC Wimbledon | 2 | 1 | Oxford | C Sarginson |
| 17/03/2018 | Oxford | 2 | 1 | Peterboro | R Lewis |
| 25/03/2018 | Portsmouth | 3 | 0 | Oxford | C Breakspear |
| 30/03/2018 | Oxford | 1 | 1 | Scunthorpe | D Drysdale |
| 02/04/2018 | Shrewsbury | 3 | 2 | Oxford | S Stockbridge |
| 07/04/2018 | Oxford | 0 | 0 | Oldham | E Ilderton |
| 10/04/2018 | Oxford | 0 | 1 | Fleetwood Town | B Malone |
| 14/04/2018 | Oxford | 2 | 0 | Southend | D Handley |
| 17/04/2018 | Wigan | 1 | 0 | Oxford | T Kettle |
| 21/04/2018 | Doncaster | 0 | 1 | Oxford | M Coy |
| 28/04/2018 | Oxford | 2 | 1 | Rochdale | N Kinseley |
| 05/05/2018 | Blackburn | 2 | 1 | Oxford | C Boyeson |