Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Shrewsbury | 1 | 0 | Northampton | S Stockbridge |
| 12/08/2017 | Northampton | 0 | 1 | Fleetwood Town | B Huxtable |
| 19/08/2017 | Charlton | 4 | 1 | Northampton | K Johnson |
| 26/08/2017 | Northampton | 1 | 4 | Peterboro | R East |
| 09/09/2017 | Northampton | 1 | 0 | Doncaster | D Handley |
| 12/09/2017 | Northampton | 3 | 1 | Portsmouth | D Drysdale |
| 16/09/2017 | Southend | 2 | 2 | Northampton | N Kinseley |
| 19/09/2017 | Wigan | 1 | 0 | Northampton | A Backhouse |
| 23/09/2017 | Northampton | 0 | 1 | Bradford | G Horwood |
| 26/09/2017 | Milton Keynes Dons | 0 | 0 | Northampton | C Sarginson |
| 30/09/2017 | Rotherham | 1 | 0 | Northampton | T Kettle |
| 07/10/2017 | Northampton | 0 | 6 | Bristol Rvs | M Heywood |
| 14/10/2017 | Northampton | 0 | 1 | AFC Wimbledon | G Salisbury |
| 17/10/2017 | Rochdale | 2 | 2 | Northampton | D Drysdale |
| 21/10/2017 | Gillingham | 1 | 2 | Northampton | R Joyce |
| 28/10/2017 | Northampton | 1 | 0 | Blackpool | J Busby |
| 11/11/2017 | Oxford | 1 | 2 | Northampton | K Johnson |
| 18/11/2017 | Northampton | 0 | 3 | Scunthorpe | M Salisbury |
| 21/11/2017 | Plymouth | 2 | 0 | Northampton | A Coggins |
| 25/11/2017 | Northampton | 0 | 0 | Bury | C Boyeson |
| 09/12/2017 | Oldham | 5 | 1 | Northampton | G Salisbury |
| 16/12/2017 | Northampton | 2 | 1 | Walsall | C Breakspear |
| 23/12/2017 | Northampton | 1 | 1 | Blackburn | G Ward |
| 26/12/2017 | Doncaster | 3 | 0 | Northampton | B Toner |
| 30/12/2017 | Portsmouth | 3 | 1 | Northampton | L Swabey |
| 01/01/2018 | Northampton | 0 | 1 | Wigan | M Heywood |
| 06/01/2018 | Northampton | 3 | 1 | Southend | M Salisbury |
| 13/01/2018 | Bradford | 1 | 2 | Northampton | C Hicks |
| 20/01/2018 | Northampton | 2 | 1 | Milton Keynes Dons | B Huxtable |
| 27/01/2018 | Blackburn | 1 | 1 | Northampton | A Backhouse |
| 03/02/2018 | Northampton | 0 | 1 | Rochdale | J Busby |
| 10/02/2018 | AFC Wimbledon | 1 | 3 | Northampton | C Boyeson |
| 13/02/2018 | Northampton | 1 | 2 | Gillingham | C Breakspear |
| 17/02/2018 | Scunthorpe | 2 | 2 | Northampton | A Madley |
| 24/02/2018 | Northampton | 0 | 0 | Oxford | M Coy |
| 10/03/2018 | Bristol Rvs | 1 | 1 | Northampton | E Ilderton |
| 17/03/2018 | Northampton | 0 | 3 | Rotherham | B Toner |
| 20/03/2018 | Northampton | 1 | 1 | Shrewsbury | A Davies |
| 24/03/2018 | Fleetwood Town | 2 | 0 | Northampton | R Lewis |
| 30/03/2018 | Northampton | 0 | 4 | Charlton | G Ward |
| 02/04/2018 | Peterboro | 2 | 0 | Northampton | M Salisbury |
| 10/04/2018 | Blackpool | 3 | 0 | Northampton | C Sarginson |
| 14/04/2018 | Bury | 2 | 3 | Northampton | T Kettle |
| 21/04/2018 | Northampton | 2 | 0 | Plymouth | L Collins |
| 28/04/2018 | Walsall | 1 | 0 | Northampton | S Stockbridge |
| 05/05/2018 | Northampton | 2 | 2 | Oldham | K Stroud |