Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Luton | 8 | 2 | Yeovil | G Ward |
| 12/08/2017 | Barnet | 1 | 0 | Luton | K Johnson |
| 19/08/2017 | Luton | 3 | 0 | Colchester | S Stockbridge |
| 26/08/2017 | Mansfield | 2 | 2 | Luton | R Joyce |
| 02/09/2017 | Lincoln | 0 | 0 | Luton | T Nield |
| 09/09/2017 | Luton | 0 | 3 | Swindon | G Salisbury |
| 12/09/2017 | Luton | 2 | 0 | Port Vale | D Webb |
| 16/09/2017 | Wycombe | 1 | 2 | Luton | J Linington |
| 23/09/2017 | Luton | 1 | 0 | Chesterfield | C Breakspear |
| 26/09/2017 | Morecambe | 0 | 0 | Luton | D Handley |
| 30/09/2017 | Luton | 3 | 1 | Newport County | M Heywood |
| 07/10/2017 | Accrington | 0 | 2 | Luton | M Coy |
| 14/10/2017 | Luton | 7 | 1 | Stevenage | B Huxtable |
| 17/10/2017 | Exeter | 1 | 4 | Luton | J Linington |
| 21/10/2017 | Crawley Town | 0 | 0 | Luton | T Kettle |
| 28/10/2017 | Luton | 0 | 3 | Coventry | R Jones |
| 11/11/2017 | Cheltenham | 2 | 2 | Luton | R Lewis |
| 18/11/2017 | Luton | 7 | 0 | Cambridge | N Kinseley |
| 21/11/2017 | Luton | 3 | 0 | Carlisle | C Sarginson |
| 25/11/2017 | Crewe | 1 | 2 | Luton | G Salisbury |
| 09/12/2017 | Luton | 1 | 1 | Notts County | C Breakspear |
| 16/12/2017 | Forest Green | 0 | 2 | Luton | L Swabey |
| 23/12/2017 | Luton | 2 | 0 | Grimsby | C Sarginson |
| 26/12/2017 | Swindon | 0 | 5 | Luton | G Ward |
| 30/12/2017 | Port Vale | 4 | 0 | Luton | T Nield |
| 01/01/2018 | Luton | 4 | 2 | Lincoln | N Kinseley |
| 13/01/2018 | Chesterfield | 2 | 0 | Luton | C Boyeson |
| 20/01/2018 | Luton | 1 | 0 | Morecambe | T Kettle |
| 27/01/2018 | Grimsby | 0 | 1 | Luton | M Salisbury |
| 30/01/2018 | Luton | 2 | 3 | Wycombe | T Robinson |
| 03/02/2018 | Luton | 1 | 0 | Exeter | A Woolmer |
| 10/02/2018 | Stevenage | 1 | 1 | Luton | D Handley |
| 13/02/2018 | Luton | 4 | 1 | Crawley Town | C Hicks |
| 24/02/2018 | Luton | 2 | 2 | Cheltenham | M Heywood |
| 03/03/2018 | Cambridge | 1 | 1 | Luton | J Brooks |
| 10/03/2018 | Luton | 1 | 2 | Accrington | D Drysdale |
| 13/03/2018 | Coventry | 2 | 2 | Luton | C Breakspear |
| 17/03/2018 | Newport County | 1 | 1 | Luton | C Hicks |
| 24/03/2018 | Luton | 2 | 0 | Barnet | M Salisbury |
| 30/03/2018 | Colchester | 2 | 1 | Luton | T Kettle |
| 02/04/2018 | Luton | 2 | 1 | Mansfield | K Johnson |
| 07/04/2018 | Yeovil | 0 | 3 | Luton | B Malone |
| 14/04/2018 | Luton | 3 | 1 | Crewe | B Toner |
| 21/04/2018 | Carlisle | 1 | 1 | Luton | S Stockbridge |
| 28/04/2018 | Luton | 3 | 1 | Forest Green | L Collins |
| 05/05/2018 | Notts County | 0 | 0 | Luton | D Handley |