Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Chesterfield | 1 | 3 | Grimsby | E Ilderton |
| 12/08/2017 | Grimsby | 0 | 2 | Coventry | R Clark |
| 19/08/2017 | Stevenage | 3 | 1 | Grimsby | S Oldham |
| 26/08/2017 | Grimsby | 2 | 3 | Wycombe | M Heywood |
| 02/09/2017 | Grimsby | 1 | 0 | Crewe | C Sarginson |
| 09/09/2017 | Mansfield | 4 | 1 | Grimsby | P Tierney |
| 12/09/2017 | Accrington | 1 | 2 | Grimsby | R Jones |
| 16/09/2017 | Grimsby | 2 | 1 | Yeovil | G Horwood |
| 23/09/2017 | Newport County | 1 | 0 | Grimsby | A Coggins |
| 26/09/2017 | Grimsby | 2 | 2 | Colchester | D Drysdale |
| 30/09/2017 | Grimsby | 0 | 0 | Lincoln | C Boyeson |
| 07/10/2017 | Port Vale | 1 | 2 | Grimsby | A Woolmer |
| 14/10/2017 | Grimsby | 0 | 0 | Crawley Town | G Ward |
| 17/10/2017 | Cheltenham | 2 | 3 | Grimsby | G Salisbury |
| 21/10/2017 | Morecambe | 0 | 0 | Grimsby | B Toner |
| 28/10/2017 | Grimsby | 0 | 0 | Cambridge | S Stockbridge |
| 11/11/2017 | Exeter | 2 | 0 | Grimsby | D Whitestone |
| 18/11/2017 | Grimsby | 0 | 1 | Carlisle | R Lewis |
| 21/11/2017 | Grimsby | 3 | 2 | Swindon | M Coy |
| 25/11/2017 | Barnet | 0 | 2 | Grimsby | G Ward |
| 09/12/2017 | Grimsby | 1 | 0 | Forest Green | C Boyeson |
| 16/12/2017 | Notts County | 0 | 0 | Grimsby | C Hicks |
| 23/12/2017 | Luton | 2 | 0 | Grimsby | C Sarginson |
| 26/12/2017 | Grimsby | 1 | 1 | Mansfield | D England |
| 30/12/2017 | Grimsby | 0 | 3 | Accrington | D Drysdale |
| 01/01/2018 | Crewe | 2 | 0 | Grimsby | S Stockbridge |
| 06/01/2018 | Grimsby | 0 | 2 | Morecambe | A Backhouse |
| 13/01/2018 | Grimsby | 1 | 2 | Newport County | G Salisbury |
| 20/01/2018 | Colchester | 1 | 1 | Grimsby | C Hicks |
| 27/01/2018 | Grimsby | 0 | 1 | Luton | M Salisbury |
| 30/01/2018 | Yeovil | 3 | 0 | Grimsby | C Breakspear |
| 03/02/2018 | Grimsby | 1 | 1 | Cheltenham | D Webb |
| 10/02/2018 | Crawley Town | 3 | 0 | Grimsby | K Johnson |
| 17/02/2018 | Cambridge | 3 | 1 | Grimsby | D Whitestone |
| 24/02/2018 | Grimsby | 0 | 1 | Exeter | A Haines |
| 03/03/2018 | Carlisle | 2 | 0 | Grimsby | S Oldham |
| 10/03/2018 | Grimsby | 1 | 1 | Port Vale | S Stockbridge |
| 17/03/2018 | Lincoln | 3 | 1 | Grimsby | D Coote |
| 24/03/2018 | Coventry | 4 | 0 | Grimsby | O Yates |
| 30/03/2018 | Grimsby | 0 | 0 | Stevenage | M Coy |
| 02/04/2018 | Wycombe | 2 | 1 | Grimsby | C Sarginson |
| 07/04/2018 | Grimsby | 1 | 0 | Chesterfield | R Madley |
| 14/04/2018 | Grimsby | 2 | 2 | Barnet | D Bond |
| 21/04/2018 | Swindon | 0 | 1 | Grimsby | J Brooks |
| 28/04/2018 | Grimsby | 2 | 1 | Notts County | C Boyeson |
| 05/05/2018 | Forest Green | 0 | 3 | Grimsby | S Stockbridge |