Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Crewe | 2 | 2 | Mansfield | G Salisbury |
| 12/08/2017 | Crewe | 1 | 1 | Newport County | E Ilderton |
| 19/08/2017 | Crewe | 1 | 0 | Barnet | A Backhouse |
| 26/08/2017 | Port Vale | 0 | 1 | Crewe | D Handley |
| 02/09/2017 | Grimsby | 1 | 0 | Crewe | C Sarginson |
| 09/09/2017 | Crewe | 5 | 1 | Chesterfield | M Coy |
| 12/09/2017 | Crewe | 0 | 1 | Cambridge | G Salisbury |
| 16/09/2017 | Exeter | 3 | 0 | Crewe | A Coggins |
| 23/09/2017 | Crewe | 0 | 5 | Carlisle | R Joyce |
| 26/09/2017 | Wycombe | 3 | 2 | Crewe | A Haines |
| 30/09/2017 | Coventry | 1 | 0 | Crewe | D Whitestone |
| 07/10/2017 | Crewe | 1 | 0 | Stevenage | T Kettle |
| 14/10/2017 | Yeovil | 2 | 0 | Crewe | B Toner |
| 17/10/2017 | Crewe | 2 | 0 | Notts County | R Jones |
| 21/10/2017 | Crewe | 0 | 2 | Accrington | A Backhouse |
| 28/10/2017 | Colchester | 3 | 1 | Crewe | K Johnson |
| 11/11/2017 | Crewe | 1 | 4 | Lincoln | C Hicks |
| 18/11/2017 | Forest Green | 3 | 2 | Crewe | C Sarginson |
| 21/11/2017 | Morecambe | 0 | 1 | Crewe | S Oldham |
| 25/11/2017 | Crewe | 1 | 2 | Luton | G Salisbury |
| 09/12/2017 | Cheltenham | 1 | 0 | Crewe | D Whitestone |
| 16/12/2017 | Crewe | 3 | 0 | Crawley Town | B Toner |
| 23/12/2017 | Crewe | 0 | 3 | Swindon | E Ilderton |
| 26/12/2017 | Chesterfield | 0 | 2 | Crewe | T Nield |
| 30/12/2017 | Cambridge | 3 | 1 | Crewe | C Hicks |
| 01/01/2018 | Crewe | 2 | 0 | Grimsby | S Stockbridge |
| 13/01/2018 | Carlisle | 1 | 0 | Crewe | C Sarginson |
| 20/01/2018 | Crewe | 2 | 3 | Wycombe | M Coy |
| 27/01/2018 | Swindon | 4 | 3 | Crewe | G Salisbury |
| 03/02/2018 | Notts County | 4 | 1 | Crewe | B Huxtable |
| 10/02/2018 | Crewe | 0 | 0 | Yeovil | R Lewis |
| 13/02/2018 | Accrington | 1 | 0 | Crewe | D Webb |
| 17/02/2018 | Crewe | 1 | 0 | Colchester | M Salisbury |
| 20/02/2018 | Crewe | 1 | 2 | Exeter | B Toner |
| 24/02/2018 | Lincoln | 1 | 4 | Crewe | C Boyeson |
| 10/03/2018 | Stevenage | 2 | 2 | Crewe | G Horwood |
| 17/03/2018 | Crewe | 1 | 2 | Coventry | A Coggins |
| 20/03/2018 | Crewe | 3 | 1 | Forest Green | A Backhouse |
| 24/03/2018 | Newport County | 1 | 2 | Crewe | D Handley |
| 30/03/2018 | Barnet | 2 | 1 | Crewe | L Swabey |
| 02/04/2018 | Crewe | 2 | 2 | Port Vale | A Woolmer |
| 07/04/2018 | Mansfield | 3 | 4 | Crewe | R Clark |
| 14/04/2018 | Luton | 3 | 1 | Crewe | B Toner |
| 21/04/2018 | Crewe | 1 | 0 | Morecambe | C Breakspear |
| 28/04/2018 | Crawley Town | 1 | 2 | Crewe | T Nield |
| 05/05/2018 | Crewe | 2 | 1 | Cheltenham | M Salisbury |