Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Carlisle | 1 | 2 | Swindon | A Haines |
| 12/08/2017 | Cambridge | 1 | 2 | Carlisle | T Nield |
| 19/08/2017 | Carlisle | 3 | 0 | Cheltenham | M Coy |
| 26/08/2017 | Lincoln | 4 | 1 | Carlisle | E Ilderton |
| 02/09/2017 | Carlisle | 1 | 1 | Mansfield | D Handley |
| 09/09/2017 | Accrington | 3 | 0 | Carlisle | D Webb |
| 12/09/2017 | Coventry | 2 | 0 | Carlisle | T Kettle |
| 16/09/2017 | Carlisle | 1 | 1 | Barnet | S Oldham |
| 23/09/2017 | Crewe | 0 | 5 | Carlisle | R Joyce |
| 26/09/2017 | Carlisle | 0 | 2 | Stevenage | M Salisbury |
| 30/09/2017 | Crawley Town | 0 | 1 | Carlisle | K Johnson |
| 07/10/2017 | Carlisle | 0 | 1 | Exeter | E Ilderton |
| 14/10/2017 | Colchester | 0 | 1 | Carlisle | C Breakspear |
| 17/10/2017 | Carlisle | 3 | 3 | Wycombe | S Duncan |
| 21/10/2017 | Carlisle | 1 | 1 | Notts County | D Webb |
| 28/10/2017 | Chesterfield | 2 | 2 | Carlisle | B Huxtable |
| 11/11/2017 | Carlisle | 4 | 0 | Yeovil | B Toner |
| 18/11/2017 | Grimsby | 0 | 1 | Carlisle | R Lewis |
| 21/11/2017 | Luton | 3 | 0 | Carlisle | C Sarginson |
| 25/11/2017 | Carlisle | 1 | 1 | Morecambe | D Handley |
| 09/12/2017 | Newport County | 3 | 3 | Carlisle | L Swabey |
| 16/12/2017 | Carlisle | 1 | 2 | Port Vale | M Salisbury |
| 23/12/2017 | Forest Green | 0 | 1 | Carlisle | K Johnson |
| 26/12/2017 | Carlisle | 3 | 1 | Accrington | S Martin |
| 30/12/2017 | Carlisle | 0 | 1 | Coventry | S Oldham |
| 01/01/2018 | Mansfield | 3 | 1 | Carlisle | D Drysdale |
| 13/01/2018 | Carlisle | 1 | 0 | Crewe | C Sarginson |
| 20/01/2018 | Stevenage | 0 | 0 | Carlisle | C Breakspear |
| 27/01/2018 | Carlisle | 1 | 0 | Forest Green | E Ilderton |
| 03/02/2018 | Wycombe | 4 | 3 | Carlisle | C Boyeson |
| 10/02/2018 | Carlisle | 1 | 1 | Colchester | R Joyce |
| 13/02/2018 | Notts County | 2 | 1 | Carlisle | D Drysdale |
| 17/02/2018 | Carlisle | 2 | 0 | Chesterfield | S Stockbridge |
| 20/02/2018 | Barnet | 1 | 3 | Carlisle | C Sarginson |
| 24/02/2018 | Yeovil | 0 | 1 | Carlisle | A Coggins |
| 03/03/2018 | Carlisle | 2 | 0 | Grimsby | S Oldham |
| 10/03/2018 | Exeter | 1 | 1 | Carlisle | J Busby |
| 17/03/2018 | Carlisle | 2 | 2 | Crawley Town | M Coy |
| 24/03/2018 | Carlisle | 1 | 1 | Cambridge | R Clark |
| 30/03/2018 | Cheltenham | 0 | 1 | Carlisle | N Kinseley |
| 02/04/2018 | Carlisle | 0 | 1 | Lincoln | R Lewis |
| 07/04/2018 | Swindon | 0 | 0 | Carlisle | B Huxtable |
| 14/04/2018 | Morecambe | 1 | 1 | Carlisle | J Brooks |
| 21/04/2018 | Carlisle | 1 | 1 | Luton | S Stockbridge |
| 28/04/2018 | Port Vale | 1 | 2 | Carlisle | B Toner |
| 05/05/2018 | Carlisle | 1 | 1 | Newport County | M Heywood |