Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2016 | Oxford | 1 | 1 | Chesterfield | G Ward |
| 14/08/2016 | Bristol Rvs | 2 | 1 | Oxford | C Breakspear |
| 17/08/2016 | Fleetwood Town | 2 | 0 | Oxford | D Webb |
| 20/08/2016 | Oxford | 2 | 1 | Peterboro | S Stockbridge |
| 27/08/2016 | Sheffield United | 2 | 1 | Oxford | N Kinseley |
| 03/09/2016 | Oxford | 1 | 0 | Rochdale | B Malone |
| 10/09/2016 | Oxford | 2 | 0 | Swindon | S Attwell |
| 17/09/2016 | Milton Keynes Dons | 0 | 0 | Oxford | L Probert |
| 24/09/2016 | Oxford | 1 | 1 | Charlton | K Stroud |
| 27/09/2016 | Southend | 2 | 1 | Oxford | G Horwood |
| 01/10/2016 | Bolton | 0 | 2 | Oxford | M Haywood |
| 09/10/2016 | Oxford | 1 | 3 | AFC Wimbledon | D Deadman |
| 15/10/2016 | Oxford | 1 | 0 | Bradford | D Webb |
| 18/10/2016 | Coventry | 2 | 1 | Oxford | R Jones |
| 22/10/2016 | Port Vale | 2 | 2 | Oxford | B Toner |
| 29/10/2016 | Oxford | 1 | 2 | Millwall | R East |
| 12/11/2016 | Shrewsbury | 2 | 0 | Oxford | C Boyeson |
| 19/11/2016 | Oxford | 4 | 1 | Coventry | D England |
| 22/11/2016 | Oxford | 1 | 0 | Gillingham | A Madley |
| 26/11/2016 | Scunthorpe | 1 | 1 | Oxford | M Salisbury |
| 10/12/2016 | Oxford | 1 | 1 | Oldham | B Huxtable |
| 17/12/2016 | Bury | 2 | 3 | Oxford | D Deadman |
| 26/12/2016 | Oxford | 0 | 1 | Northampton | J Brooks |
| 31/12/2016 | Oxford | 0 | 0 | Walsall | C Breakspear |
| 02/01/2017 | Gillingham | 0 | 1 | Oxford | L Swabey |
| 14/01/2017 | AFC Wimbledon | 2 | 1 | Oxford | M Haywood |
| 21/01/2017 | Rochdale | 0 | 4 | Oxford | R Jones |
| 05/02/2017 | Swindon | 1 | 2 | Oxford | D Deadman |
| 11/02/2017 | Oxford | 1 | 0 | Milton Keynes Dons | T Kettle |
| 14/02/2017 | Oxford | 0 | 2 | Southend | D England |
| 21/02/2017 | Charlton | 0 | 1 | Oxford | G Ward |
| 25/02/2017 | Chesterfield | 0 | 4 | Oxford | D Webb |
| 04/03/2017 | Oxford | 0 | 2 | Bristol Rvs | C Boyeson |
| 07/03/2017 | Oxford | 2 | 3 | Sheffield United | P Tierney |
| 11/03/2017 | Peterboro | 1 | 2 | Oxford | M Heywood |
| 14/03/2017 | Oldham | 2 | 1 | Oxford | D Drysdale |
| 18/03/2017 | Oxford | 2 | 1 | Scunthorpe | T Robinson |
| 21/03/2017 | Oxford | 2 | 4 | Bolton | R Joyce |
| 25/03/2017 | Northampton | 0 | 0 | Oxford | M Jones |
| 28/03/2017 | Oxford | 5 | 1 | Bury | A Haines |
| 05/04/2017 | Oxford | 1 | 3 | Fleetwood Town | G Horwood |
| 08/04/2017 | Walsall | 1 | 1 | Oxford | D Handley |
| 14/04/2017 | Bradford | 1 | 0 | Oxford | R Clark |
| 17/04/2017 | Oxford | 2 | 0 | Port Vale | T Kettle |
| 22/04/2017 | Millwall | 0 | 3 | Oxford | D Whitestone |
| 30/04/2017 | Oxford | 2 | 0 | Shrewsbury | K Johnson |