Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Coventry | 2 | 0 | Wigan | S Duncan |
| 16/08/2015 | Wigan | 0 | 0 | Doncaster | D Webb |
| 19/08/2015 | Wigan | 3 | 0 | Scunthorpe | A Madley |
| 22/08/2015 | Gillingham | 2 | 0 | Wigan | I Williamson |
| 29/08/2015 | Wigan | 1 | 0 | Crewe | D Coote |
| 05/09/2015 | Chesterfield | 2 | 3 | Wigan | M Brown |
| 12/09/2015 | Port Vale | 3 | 2 | Wigan | M Haywood |
| 19/09/2015 | Wigan | 2 | 1 | Fleetwood Town | F Graham |
| 26/09/2015 | Oldham | 1 | 1 | Wigan | D Handley |
| 29/09/2015 | Wigan | 2 | 2 | Millwall | G Eltringham |
| 03/10/2015 | Wigan | 0 | 0 | Walsall | A Haines |
| 10/10/2015 | Bury | 2 | 2 | Wigan | G Salisbury |
| 17/10/2015 | Wigan | 5 | 0 | Colchester | S Martin |
| 20/10/2015 | Peterboro | 2 | 3 | Wigan | O Langford |
| 24/10/2015 | Bradford | 1 | 1 | Wigan | R Clark |
| 31/10/2015 | Wigan | 1 | 0 | Swindon | N Miller |
| 14/11/2015 | Rochdale | 0 | 2 | Wigan | N Swarbrick |
| 21/11/2015 | Wigan | 1 | 0 | Shrewsbury | D Deadman |
| 24/11/2015 | Wigan | 0 | 1 | Burton | M Haywood |
| 28/11/2015 | Southend | 0 | 0 | Wigan | K Stroud |
| 12/12/2015 | Wigan | 0 | 1 | Blackpool | P Gibbs |
| 19/12/2015 | Barnsley | 0 | 2 | Wigan | S Stockbridge |
| 28/12/2015 | Fleetwood Town | 1 | 3 | Wigan | C Boyeson |
| 02/01/2016 | Scunthorpe | 1 | 1 | Wigan | C Sarginson |
| 07/01/2016 | Wigan | 3 | 2 | Gillingham | S Duncan |
| 12/01/2016 | Wigan | 3 | 3 | Sheffield United | A Woolmer |
| 16/01/2016 | Wigan | 3 | 1 | Chesterfield | R Joyce |
| 23/01/2016 | Crewe | 1 | 1 | Wigan | N Kinseley |
| 30/01/2016 | Wigan | 3 | 0 | Port Vale | D Drysdale |
| 06/02/2016 | Sheffield United | 0 | 2 | Wigan | S Martin |
| 13/02/2016 | Wigan | 0 | 0 | Oldham | N Miller |
| 20/02/2016 | Walsall | 1 | 2 | Wigan | I Williamson |
| 27/02/2016 | Wigan | 3 | 0 | Bury | S Duncan |
| 01/03/2016 | Millwall | 0 | 0 | Wigan | L Collins |
| 05/03/2016 | Wigan | 1 | 1 | Peterboro | G Eltringham |
| 12/03/2016 | Colchester | 3 | 3 | Wigan | K Johnson |
| 19/03/2016 | Wigan | 1 | 0 | Bradford | D Deadman |
| 25/03/2016 | Swindon | 1 | 4 | Wigan | A Davies |
| 28/03/2016 | Wigan | 1 | 0 | Rochdale | M Brown |
| 02/04/2016 | Shrewsbury | 1 | 5 | Wigan | N Kinseley |
| 09/04/2016 | Wigan | 1 | 0 | Coventry | D Whitestone |
| 16/04/2016 | Doncaster | 3 | 1 | Wigan | K Johnson |
| 19/04/2016 | Burton | 1 | 1 | Wigan | S Hooper |
| 23/04/2016 | Wigan | 4 | 1 | Southend | D England |
| 30/04/2016 | Blackpool | 0 | 4 | Wigan | S Attwell |
| 08/05/2016 | Wigan | 1 | 4 | Barnsley | T Harrington |