Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Oxford | 1 | 1 | Crawley Town | J Simpson |
| 15/08/2015 | Luton | 2 | 2 | Oxford | M Brown |
| 18/08/2015 | Oxford | 3 | 1 | Notts County | R Lewis |
| 22/08/2015 | Mansfield | 1 | 1 | Oxford | B Toner |
| 29/08/2015 | Oxford | 2 | 0 | Yeovil | K Johnson |
| 06/09/2015 | Bristol Rvs | 0 | 1 | Oxford | J Linington |
| 12/09/2015 | Northampton | 1 | 0 | Oxford | N Swarbrick |
| 19/09/2015 | Oxford | 1 | 1 | Portsmouth | I Williamson |
| 26/09/2015 | Oxford | 0 | 0 | Morecambe | T Robinson |
| 29/09/2015 | York | 1 | 2 | Oxford | D Webb |
| 03/10/2015 | Accrington | 1 | 3 | Oxford | M Haywood |
| 10/10/2015 | Oxford | 1 | 0 | AFC Wimbledon | F Graham |
| 17/10/2015 | Leyton Orient | 2 | 2 | Oxford | R Joyce |
| 20/10/2015 | Oxford | 1 | 0 | Plymouth | K Stroud |
| 24/10/2015 | Oxford | 2 | 3 | Barnet | D Handley |
| 31/10/2015 | Stevenage | 1 | 5 | Oxford | L Swabey |
| 14/11/2015 | Oxford | 1 | 0 | Cambridge | K Hill |
| 21/11/2015 | Dag and Red | 0 | 1 | Oxford | K Johnson |
| 24/11/2015 | Oxford | 1 | 1 | Newport County | A Madley |
| 28/11/2015 | Hartlepool | 0 | 1 | Oxford | S Stockbridge |
| 12/12/2015 | Oxford | 1 | 1 | Carlisle | M Haywood |
| 19/12/2015 | Wycombe | 2 | 1 | Oxford | N Swarbrick |
| 26/12/2015 | Oxford | 3 | 0 | Exeter | G Salisbury |
| 28/12/2015 | Yeovil | 0 | 0 | Oxford | S Martin |
| 02/01/2016 | Notts County | 2 | 4 | Oxford | C Boyeson |
| 17/01/2016 | Oxford | 1 | 2 | Bristol Rvs | N Kinseley |
| 23/01/2016 | Portsmouth | 0 | 1 | Oxford | N Swarbrick |
| 09/02/2016 | Oxford | 2 | 2 | Mansfield | J Linington |
| 13/02/2016 | Morecambe | 2 | 4 | Oxford | P Bankes |
| 16/02/2016 | Oxford | 0 | 1 | Northampton | K Hill |
| 20/02/2016 | Oxford | 1 | 2 | Accrington | L Swabey |
| 23/02/2016 | Exeter | 1 | 4 | Oxford | S Hooper |
| 27/02/2016 | AFC Wimbledon | 1 | 2 | Oxford | K Wright |
| 01/03/2016 | Oxford | 4 | 0 | York | O Langford |
| 05/03/2016 | Plymouth | 2 | 2 | Oxford | J Adcock |
| 12/03/2016 | Oxford | 0 | 1 | Leyton Orient | D Coote |
| 15/03/2016 | Oxford | 4 | 0 | Dag and Red | T Robinson |
| 19/03/2016 | Barnet | 0 | 3 | Oxford | S Duncan |
| 25/03/2016 | Oxford | 1 | 1 | Stevenage | B Malone |
| 28/03/2016 | Cambridge | 0 | 0 | Oxford | M Haywood |
| 09/04/2016 | Crawley Town | 1 | 5 | Oxford | N Kinseley |
| 16/04/2016 | Oxford | 2 | 3 | Luton | T Kettle |
| 19/04/2016 | Newport County | 1 | 1 | Oxford | G Ward |
| 23/04/2016 | Oxford | 2 | 0 | Hartlepool | C Kavanagh |
| 30/04/2016 | Carlisle | 0 | 2 | Oxford | P Gibbs |
| 07/05/2016 | Oxford | 3 | 0 | Wycombe | K Stroud |