Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 09/08/2015 | Preston | 0 | 0 | Middlesbrough | C Kavanagh |
| 15/08/2015 | Middlesbrough | 3 | 0 | Bolton | J Adcock |
| 18/08/2015 | Derby | 1 | 1 | Middlesbrough | S Martin |
| 22/08/2015 | Middlesbrough | 0 | 1 | Bristol City | P Tierney |
| 29/08/2015 | Sheffield Weds | 1 | 3 | Middlesbrough | M Heywood |
| 12/09/2015 | Middlesbrough | 2 | 0 | Milton Keynes Dons | J Simpson |
| 15/09/2015 | Middlesbrough | 3 | 1 | Brentford | G Salisbury |
| 19/09/2015 | Nott'm Forest | 1 | 2 | Middlesbrough | L Mason |
| 27/09/2015 | Middlesbrough | 3 | 0 | Leeds | N Swarbrick |
| 03/10/2015 | Reading | 2 | 0 | Middlesbrough | K Stroud |
| 17/10/2015 | Middlesbrough | 0 | 0 | Fulham | P Bankes |
| 20/10/2015 | Cardiff | 1 | 0 | Middlesbrough | D Whitestone |
| 24/10/2015 | Wolves | 1 | 3 | Middlesbrough | J Linington |
| 31/10/2015 | Middlesbrough | 3 | 0 | Charlton | A Madley |
| 03/11/2015 | Middlesbrough | 1 | 0 | Rotherham | P Tierney |
| 07/11/2015 | Hull | 3 | 0 | Middlesbrough | J Simpson |
| 20/11/2015 | Middlesbrough | 1 | 0 | QPR | C Kavanagh |
| 28/11/2015 | Huddersfield | 0 | 2 | Middlesbrough | E Ilderton |
| 04/12/2015 | Ipswich | 0 | 2 | Middlesbrough | T Robinson |
| 12/12/2015 | Middlesbrough | 0 | 0 | Birmingham | D Bond |
| 15/12/2015 | Middlesbrough | 1 | 0 | Burnley | G Eltringham |
| 19/12/2015 | Brighton | 0 | 3 | Middlesbrough | C Pawson |
| 28/12/2015 | Middlesbrough | 1 | 0 | Sheffield Weds | D Coote |
| 02/01/2016 | Middlesbrough | 2 | 0 | Derby | N Swarbrick |
| 12/01/2016 | Brentford | 0 | 1 | Middlesbrough | G Ward |
| 16/01/2016 | Bristol City | 1 | 0 | Middlesbrough | C Boyeson |
| 23/01/2016 | Middlesbrough | 0 | 1 | Nott'm Forest | F Graham |
| 06/02/2016 | Middlesbrough | 1 | 1 | Blackburn | D Whitestone |
| 09/02/2016 | Milton Keynes Dons | 1 | 1 | Middlesbrough | A Davies |
| 15/02/2016 | Leeds | 0 | 0 | Middlesbrough | C Pawson |
| 23/02/2016 | Middlesbrough | 3 | 1 | Cardiff | T Kettle |
| 27/02/2016 | Fulham | 0 | 2 | Middlesbrough | C Breakspear |
| 01/03/2016 | Blackburn | 2 | 1 | Middlesbrough | A Madley |
| 04/03/2016 | Middlesbrough | 2 | 1 | Wolves | S Atwell |
| 08/03/2016 | Rotherham | 1 | 0 | Middlesbrough | P Bankes |
| 13/03/2016 | Charlton | 2 | 0 | Middlesbrough | D Deadman |
| 18/03/2016 | Middlesbrough | 1 | 0 | Hull | A Marriner |
| 01/04/2016 | QPR | 2 | 3 | Middlesbrough | S Hooper |
| 05/04/2016 | Middlesbrough | 3 | 0 | Huddersfield | S Martin |
| 09/04/2016 | Middlesbrough | 1 | 0 | Preston | O Langford |
| 12/04/2016 | Middlesbrough | 2 | 1 | Reading | S Duncan |
| 16/04/2016 | Bolton | 1 | 2 | Middlesbrough | K Stroud |
| 19/04/2016 | Burnley | 1 | 1 | Middlesbrough | M Jones |
| 23/04/2016 | Middlesbrough | 0 | 0 | Ipswich | D Bond |
| 29/04/2016 | Birmingham | 2 | 2 | Middlesbrough | S Hooper |
| 07/05/2016 | Middlesbrough | 1 | 1 | Brighton | M Dean |