Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Leyton Orient | 2 | 0 | Barnet | I Williamson |
| 15/08/2015 | Dag and Red | 1 | 3 | Leyton Orient | G Ward |
| 18/08/2015 | Leyton Orient | 3 | 0 | Stevenage | C Sarginson |
| 22/08/2015 | Newport County | 2 | 3 | Leyton Orient | B Malone |
| 29/08/2015 | Leyton Orient | 2 | 0 | Bristol Rvs | D Drysdale |
| 05/09/2015 | Exeter | 4 | 0 | Leyton Orient | K Johnson |
| 12/09/2015 | Cambridge | 1 | 1 | Leyton Orient | O Langford |
| 19/09/2015 | Leyton Orient | 1 | 1 | Wycombe | J Linington |
| 26/09/2015 | Northampton | 1 | 1 | Leyton Orient | M Bull |
| 29/09/2015 | Leyton Orient | 1 | 2 | Carlisle | C Breakspear |
| 03/10/2015 | Leyton Orient | 3 | 1 | Notts County | D England |
| 10/10/2015 | Crawley Town | 3 | 2 | Leyton Orient | K Wright |
| 17/10/2015 | Leyton Orient | 2 | 2 | Oxford | R Joyce |
| 20/10/2015 | Luton | 1 | 1 | Leyton Orient | T Robinson |
| 24/10/2015 | Morecambe | 0 | 1 | Leyton Orient | D Webb |
| 31/10/2015 | Leyton Orient | 0 | 1 | Accrington | G Horwood |
| 15/11/2015 | Hartlepool | 3 | 1 | Leyton Orient | P Tierney |
| 21/11/2015 | Leyton Orient | 3 | 2 | York | L Collins |
| 24/11/2015 | Plymouth | 1 | 1 | Leyton Orient | A Woolmer |
| 28/11/2015 | Leyton Orient | 1 | 1 | AFC Wimbledon | D Handley |
| 12/12/2015 | Mansfield | 1 | 1 | Leyton Orient | D England |
| 19/12/2015 | Leyton Orient | 1 | 1 | Yeovil | L Swabey |
| 26/12/2015 | Leyton Orient | 3 | 2 | Portsmouth | G Horwood |
| 28/12/2015 | Bristol Rvs | 2 | 1 | Leyton Orient | K Johnson |
| 02/01/2016 | Stevenage | 2 | 2 | Leyton Orient | D Deadman |
| 16/01/2016 | Leyton Orient | 1 | 3 | Exeter | K Hill |
| 23/01/2016 | Wycombe | 0 | 2 | Leyton Orient | D Bond |
| 26/01/2016 | Leyton Orient | 1 | 0 | Newport County | A Davies |
| 30/01/2016 | Leyton Orient | 1 | 3 | Cambridge | M Bull |
| 06/02/2016 | Portsmouth | 0 | 1 | Leyton Orient | G Salisbury |
| 13/02/2016 | Leyton Orient | 0 | 4 | Northampton | P Tierney |
| 20/02/2016 | Notts County | 0 | 1 | Leyton Orient | A Woolmer |
| 27/02/2016 | Leyton Orient | 2 | 0 | Crawley Town | L Collins |
| 01/03/2016 | Carlisle | 2 | 2 | Leyton Orient | N Miller |
| 05/03/2016 | Leyton Orient | 0 | 1 | Luton | C Breakspear |
| 12/03/2016 | Oxford | 0 | 1 | Leyton Orient | D Coote |
| 19/03/2016 | Leyton Orient | 1 | 0 | Morecambe | N Kinseley |
| 25/03/2016 | Accrington | 1 | 0 | Leyton Orient | R Joyce |
| 28/03/2016 | Leyton Orient | 0 | 2 | Hartlepool | F Graham |
| 02/04/2016 | York | 1 | 1 | Leyton Orient | T Kettle |
| 09/04/2016 | Barnet | 3 | 0 | Leyton Orient | K Stroud |
| 16/04/2016 | Leyton Orient | 3 | 2 | Dag and Red | D Whitestone |
| 19/04/2016 | Leyton Orient | 1 | 3 | Plymouth | T Robinson |
| 23/04/2016 | AFC Wimbledon | 1 | 0 | Leyton Orient | G Salisbury |
| 30/04/2016 | Leyton Orient | 1 | 0 | Mansfield | G Ward |
| 07/05/2016 | Yeovil | 0 | 1 | Leyton Orient | P Gibbs |