Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 08/08/2015 | Crewe | 0 | 0 | Port Vale | D Whitestone |
| 15/08/2015 | Scunthorpe | 2 | 0 | Crewe | T Kettle |
| 18/08/2015 | Coventry | 3 | 2 | Crewe | T Robinson |
| 22/08/2015 | Crewe | 3 | 3 | Bury | O Langford |
| 29/08/2015 | Wigan | 1 | 0 | Crewe | D Coote |
| 05/09/2015 | Crewe | 1 | 3 | Swindon | R Clark |
| 12/09/2015 | Crewe | 1 | 3 | Millwall | D Handley |
| 19/09/2015 | Shrewsbury | 0 | 1 | Crewe | A Madley |
| 26/09/2015 | Walsall | 1 | 1 | Crewe | J Linington |
| 29/09/2015 | Crewe | 1 | 2 | Southend | D Bond |
| 03/10/2015 | Crewe | 1 | 2 | Chesterfield | R Joyce |
| 10/10/2015 | Barnsley | 1 | 2 | Crewe | M Brown |
| 17/10/2015 | Crewe | 0 | 1 | Gillingham | D Webb |
| 20/10/2015 | Burton | 0 | 0 | Crewe | S Stockbridge |
| 24/10/2015 | Blackpool | 2 | 0 | Crewe | M Haywood |
| 31/10/2015 | Crewe | 1 | 0 | Sheffield United | F Graham |
| 14/11/2015 | Bradford | 2 | 0 | Crewe | G Eltringham |
| 21/11/2015 | Crewe | 1 | 5 | Peterboro | C Breakspear |
| 24/11/2015 | Colchester | 2 | 3 | Crewe | C Sarginson |
| 28/11/2015 | Crewe | 1 | 0 | Oldham | S Hooper |
| 12/12/2015 | Doncaster | 3 | 2 | Crewe | D Drysdale |
| 19/12/2015 | Crewe | 1 | 1 | Fleetwood Town | A Madley |
| 28/12/2015 | Crewe | 1 | 2 | Shrewsbury | A Haines |
| 02/01/2016 | Crewe | 0 | 5 | Coventry | M Haywood |
| 16/01/2016 | Swindon | 4 | 3 | Crewe | L Collins |
| 23/01/2016 | Crewe | 1 | 1 | Wigan | N Kinseley |
| 26/01/2016 | Bury | 0 | 0 | Crewe | D England |
| 30/01/2016 | Millwall | 1 | 1 | Crewe | C Kavanagh |
| 06/02/2016 | Crewe | 2 | 0 | Rochdale | R Joyce |
| 13/02/2016 | Crewe | 1 | 1 | Walsall | D Handley |
| 16/02/2016 | Rochdale | 2 | 2 | Crewe | E Ilderton |
| 20/02/2016 | Chesterfield | 3 | 1 | Crewe | G Ward |
| 27/02/2016 | Crewe | 1 | 2 | Barnsley | S Stockbridge |
| 01/03/2016 | Southend | 1 | 1 | Crewe | D Whitestone |
| 05/03/2016 | Crewe | 1 | 1 | Burton | P Bankes |
| 12/03/2016 | Gillingham | 3 | 0 | Crewe | K Hill |
| 19/03/2016 | Crewe | 1 | 2 | Blackpool | K Johnson |
| 25/03/2016 | Sheffield United | 3 | 2 | Crewe | A Woolmer |
| 28/03/2016 | Crewe | 0 | 1 | Bradford | K Wright |
| 02/04/2016 | Peterboro | 3 | 0 | Crewe | L Collins |
| 09/04/2016 | Port Vale | 3 | 0 | Crewe | P Tierney |
| 16/04/2016 | Crewe | 2 | 3 | Scunthorpe | D England |
| 19/04/2016 | Crewe | 1 | 1 | Colchester | S Duncan |
| 23/04/2016 | Oldham | 1 | 0 | Crewe | M Bull |
| 30/04/2016 | Crewe | 3 | 1 | Doncaster | L Swabey |
| 08/05/2016 | Fleetwood Town | 2 | 0 | Crewe | J Adcock |