Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Rotherham | 1 | 0 | Oxford | D Mohareb |
| 13/08/2011 | Oxford | 1 | 1 | Bradford | J Adcock |
| 16/08/2011 | Oxford | 2 | 0 | Shrewsbury | R East |
| 21/08/2011 | Swindon | 1 | 2 | Oxford | M Haywood |
| 27/08/2011 | Oxford | 1 | 1 | Aldershot | A Madley |
| 03/09/2011 | Crewe | 3 | 1 | Oxford | G Salisbury |
| 10/09/2011 | Oxford | 2 | 2 | Burton | A Woolmer |
| 13/09/2011 | Dag and Red | 0 | 1 | Oxford | B Malone |
| 17/09/2011 | Barnet | 0 | 2 | Oxford | C Berry |
| 24/09/2011 | Oxford | 1 | 1 | Accrington | K Wright |
| 01/10/2011 | Hereford | 0 | 1 | Oxford | D Coote |
| 08/10/2011 | Oxford | 3 | 0 | Bristol Rvs | J Linnington |
| 15/10/2011 | Macclesfield | 1 | 1 | Oxford | G Eltringham |
| 22/10/2011 | Gillingham | 1 | 0 | Oxford | G Ward |
| 25/10/2011 | Oxford | 5 | 1 | Plymouth | P Gibbs |
| 29/10/2011 | Oxford | 2 | 1 | Port Vale | M Haywood |
| 05/11/2011 | Southend | 2 | 1 | Oxford | M Heywood |
| 19/11/2011 | Crawley Town | 4 | 1 | Oxford | D Whitestone |
| 26/11/2011 | Oxford | 1 | 3 | Cheltenham | J Moss |
| 10/12/2011 | Morecambe | 0 | 0 | Oxford | C Webster |
| 17/12/2011 | Oxford | 2 | 0 | Northampton | A Bates |
| 26/12/2011 | AFC Wimbledon | 0 | 2 | Oxford | A D'Urso |
| 31/12/2011 | Torquay | 0 | 0 | Oxford | K Stroud |
| 02/01/2012 | Oxford | 1 | 1 | Crawley Town | B Malone |
| 07/01/2012 | Aldershot | 0 | 3 | Oxford | P Miller |
| 14/01/2012 | Oxford | 0 | 1 | Crewe | L Collins |
| 21/01/2012 | Oxford | 2 | 2 | Hereford | I Williamson |
| 29/01/2012 | Burton | 1 | 1 | Oxford | A Haines |
| 14/02/2012 | Oxford | 2 | 1 | Dag and Red | J Waugh |
| 18/02/2012 | Bristol Rvs | 0 | 0 | Oxford | P Gibbs |
| 21/02/2012 | Oxford | 2 | 1 | Barnet | S Attwell |
| 25/02/2012 | Oxford | 1 | 1 | Macclesfield | D Drysdale |
| 03/03/2012 | Oxford | 2 | 0 | Swindon | G Salisbury |
| 06/03/2012 | Shrewsbury | 2 | 2 | Oxford | S Rushton |
| 10/03/2012 | Bradford | 2 | 1 | Oxford | C Webster |
| 17/03/2012 | Oxford | 2 | 1 | Rotherham | T Kettle |
| 20/03/2012 | Oxford | 1 | 0 | AFC Wimbledon | K Stroud |
| 24/03/2012 | Cheltenham | 0 | 0 | Oxford | P Tierney |
| 27/03/2012 | Accrington | 0 | 2 | Oxford | E Ilderton |
| 31/03/2012 | Oxford | 1 | 2 | Morecambe | A Madley |
| 06/04/2012 | Northampton | 2 | 1 | Oxford | M Brown |
| 09/04/2012 | Oxford | 2 | 2 | Torquay | D Mohareb |
| 14/04/2012 | Oxford | 0 | 0 | Gillingham | D Coote |
| 21/04/2012 | Plymouth | 1 | 1 | Oxford | G Sutton |
| 28/04/2012 | Oxford | 0 | 2 | Southend | L Collins |
| 05/05/2012 | Port Vale | 3 | 0 | Oxford | D Drysdale |