Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Macclesfield | 0 | 1 | Dag and Red | D Whitestone |
| 13/08/2011 | Crawley Town | 2 | 0 | Macclesfield | A D'Urso |
| 16/08/2011 | Hereford | 0 | 4 | Macclesfield | D Sheldrake |
| 20/08/2011 | Macclesfield | 0 | 0 | Bristol Rvs | A Madley |
| 27/08/2011 | Macclesfield | 4 | 0 | AFC Wimbledon | C Boyeson |
| 03/09/2011 | Torquay | 3 | 0 | Macclesfield | I Williamson |
| 10/09/2011 | Cheltenham | 2 | 0 | Macclesfield | D Phillips |
| 13/09/2011 | Macclesfield | 1 | 1 | Morecambe | S Hooper |
| 17/09/2011 | Macclesfield | 3 | 1 | Northampton | M Haywood |
| 24/09/2011 | Plymouth | 2 | 0 | Macclesfield | R East |
| 30/09/2011 | Macclesfield | 2 | 0 | Swindon | S Rushton |
| 08/10/2011 | Aldershot | 1 | 2 | Macclesfield | P Gibbs |
| 15/10/2011 | Macclesfield | 1 | 1 | Oxford | G Eltringham |
| 22/10/2011 | Crewe | 0 | 1 | Macclesfield | A Bates |
| 25/10/2011 | Macclesfield | 1 | 0 | Bradford | R Lewis |
| 29/10/2011 | Macclesfield | 0 | 2 | Southend | M Brown |
| 05/11/2011 | Burton | 1 | 0 | Macclesfield | B Malone |
| 19/11/2011 | Macclesfield | 1 | 1 | Accrington | M Naylor |
| 25/11/2011 | Barnet | 2 | 1 | Macclesfield | D Whitestone |
| 10/12/2011 | Macclesfield | 0 | 0 | Gillingham | G Salisbury |
| 17/12/2011 | Shrewsbury | 1 | 0 | Macclesfield | S Tanner |
| 26/12/2011 | Macclesfield | 0 | 0 | Rotherham | S Mathieson |
| 31/12/2011 | Macclesfield | 2 | 1 | Port Vale | P Tierney |
| 02/01/2012 | Accrington | 4 | 0 | Macclesfield | G Sutton |
| 14/01/2012 | Macclesfield | 1 | 2 | Torquay | D Webb |
| 21/01/2012 | Swindon | 1 | 0 | Macclesfield | K Stroud |
| 24/01/2012 | AFC Wimbledon | 2 | 1 | Macclesfield | F Graham |
| 28/01/2012 | Macclesfield | 1 | 3 | Cheltenham | C Pawson |
| 14/02/2012 | Morecambe | 1 | 0 | Macclesfield | C Webster |
| 18/02/2012 | Macclesfield | 0 | 1 | Aldershot | T Kettle |
| 21/02/2012 | Northampton | 3 | 2 | Macclesfield | G Scott |
| 25/02/2012 | Oxford | 1 | 1 | Macclesfield | D Drysdale |
| 28/02/2012 | Macclesfield | 1 | 1 | Plymouth | A Haines |
| 03/03/2012 | Bristol Rvs | 0 | 0 | Macclesfield | G Ward |
| 06/03/2012 | Macclesfield | 2 | 2 | Hereford | D Webb |
| 10/03/2012 | Macclesfield | 2 | 2 | Crawley Town | E Ilderton |
| 17/03/2012 | Dag and Red | 2 | 0 | Macclesfield | D Phillips |
| 20/03/2012 | Rotherham | 4 | 2 | Macclesfield | P Gibbs |
| 23/03/2012 | Macclesfield | 0 | 0 | Barnet | D Coote |
| 31/03/2012 | Gillingham | 2 | 0 | Macclesfield | D McDermid |
| 06/04/2012 | Macclesfield | 1 | 3 | Shrewsbury | P Tierney |
| 09/04/2012 | Port Vale | 1 | 0 | Macclesfield | C Pawson |
| 14/04/2012 | Macclesfield | 2 | 2 | Crewe | N Miller |
| 21/04/2012 | Bradford | 1 | 0 | Macclesfield | G Ward |
| 28/04/2012 | Macclesfield | 0 | 2 | Burton | O Langford |
| 05/05/2012 | Southend | 2 | 0 | Macclesfield | J Adcock |