Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Walsall | 1 | 0 | Leyton Orient | J Waugh |
| 13/08/2011 | Leyton Orient | 0 | 1 | Tranmere | J Linington |
| 16/08/2011 | Leyton Orient | 1 | 3 | Wycombe | G Ward |
| 20/08/2011 | Brentford | 5 | 0 | Leyton Orient | A Haines |
| 27/08/2011 | Leyton Orient | 1 | 2 | Carlisle | D Whitestone |
| 03/09/2011 | Chesterfield | 0 | 0 | Leyton Orient | G Sutton |
| 10/09/2011 | Colchester | 1 | 1 | Leyton Orient | A D'Urso |
| 13/09/2011 | Leyton Orient | 1 | 3 | Bournemouth | D Coote |
| 17/09/2011 | Leyton Orient | 1 | 3 | Oldham | R East |
| 24/09/2011 | Huddersfield | 2 | 2 | Leyton Orient | R Lewis |
| 01/10/2011 | Leyton Orient | 2 | 1 | Preston | A Madley |
| 08/10/2011 | Scunthorpe | 2 | 3 | Leyton Orient | M Heywood |
| 15/10/2011 | Leyton Orient | 1 | 0 | Bury | D Deadman |
| 22/10/2011 | Leyton Orient | 1 | 1 | Sheffield United | O Langford |
| 25/10/2011 | Yeovil | 2 | 2 | Leyton Orient | L Collins |
| 29/10/2011 | Rochdale | 0 | 2 | Leyton Orient | J Adcock |
| 05/11/2011 | Leyton Orient | 1 | 1 | Hartlepool | C Pawson |
| 19/11/2011 | Leyton Orient | 0 | 0 | Stevenage | C Berry |
| 26/11/2011 | Sheffield Weds | 1 | 0 | Leyton Orient | S Mathieson |
| 10/12/2011 | Leyton Orient | 3 | 0 | Exeter | A D'Urso |
| 17/12/2011 | Notts County | 1 | 2 | Leyton Orient | A Haines |
| 26/12/2011 | Leyton Orient | 0 | 3 | Milton Keynes Dons | D Phillips |
| 31/12/2011 | Leyton Orient | 1 | 0 | Charlton | D Whitestone |
| 02/01/2012 | Stevenage | 0 | 1 | Leyton Orient | D Sheldrake |
| 07/01/2012 | Carlisle | 4 | 1 | Leyton Orient | C Sarginson |
| 14/01/2012 | Leyton Orient | 1 | 1 | Chesterfield | G Scott |
| 21/01/2012 | Preston | 0 | 2 | Leyton Orient | A Woolmer |
| 28/01/2012 | Leyton Orient | 0 | 1 | Colchester | M Haywood |
| 14/02/2012 | Bournemouth | 1 | 2 | Leyton Orient | I Williamson |
| 18/02/2012 | Leyton Orient | 1 | 3 | Scunthorpe | D Sheldrake |
| 25/02/2012 | Bury | 1 | 1 | Leyton Orient | R Madley |
| 03/03/2012 | Leyton Orient | 1 | 1 | Walsall | A D'Urso |
| 06/03/2012 | Wycombe | 4 | 2 | Leyton Orient | D Phillips |
| 10/03/2012 | Tranmere | 2 | 0 | Leyton Orient | A Madley |
| 17/03/2012 | Leyton Orient | 2 | 0 | Brentford | P Tierney |
| 20/03/2012 | Milton Keynes Dons | 4 | 1 | Leyton Orient | D McDermid |
| 24/03/2012 | Leyton Orient | 0 | 1 | Sheffield Weds | D Drysdale |
| 27/03/2012 | Oldham | 0 | 1 | Leyton Orient | C Boyeson |
| 31/03/2012 | Charlton | 2 | 0 | Leyton Orient | M Brown |
| 03/04/2012 | Leyton Orient | 1 | 3 | Huddersfield | J Linington |
| 06/04/2012 | Leyton Orient | 0 | 3 | Notts County | D Webb |
| 09/04/2012 | Exeter | 3 | 0 | Leyton Orient | D Sheldrake |
| 14/04/2012 | Sheffield United | 3 | 1 | Leyton Orient | A Bates |
| 21/04/2012 | Leyton Orient | 2 | 2 | Yeovil | A Haines |
| 28/04/2012 | Hartlepool | 2 | 1 | Leyton Orient | S Rushton |
| 05/05/2012 | Leyton Orient | 2 | 1 | Rochdale | S Attwell |