Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 06/08/2011 | Swindon | 3 | 0 | Crewe | M Naylor |
| 13/08/2011 | Crewe | 1 | 2 | Gillingham | P Gibbs |
| 16/08/2011 | Crewe | 1 | 2 | Rotherham | P Tierney |
| 20/08/2011 | Shrewsbury | 2 | 0 | Crewe | G Sutton |
| 27/08/2011 | Plymouth | 0 | 1 | Crewe | L Collins |
| 03/09/2011 | Crewe | 3 | 1 | Oxford | G Salisbury |
| 10/09/2011 | Crewe | 3 | 1 | Barnet | J Adcock |
| 13/09/2011 | Burton | 1 | 0 | Crewe | D Drysdale |
| 17/09/2011 | Accrington | 0 | 2 | Crewe | A Madley |
| 24/09/2011 | Crewe | 1 | 1 | Port Vale | N Swarbrick |
| 01/10/2011 | Dag and Red | 2 | 1 | Crewe | C Pawson |
| 08/10/2011 | Crewe | 1 | 3 | Southend | M Haywood |
| 15/10/2011 | AFC Wimbledon | 1 | 3 | Crewe | D Phillips |
| 22/10/2011 | Crewe | 0 | 1 | Macclesfield | A Bates |
| 25/10/2011 | Cheltenham | 0 | 1 | Crewe | K Stroud |
| 29/10/2011 | Aldershot | 3 | 1 | Crewe | B Malone |
| 05/11/2011 | Crewe | 0 | 3 | Torquay | G Eltringham |
| 19/11/2011 | Morecambe | 1 | 2 | Crewe | N Miller |
| 26/11/2011 | Crewe | 1 | 0 | Hereford | M Brown |
| 10/12/2011 | Northampton | 1 | 1 | Crewe | S Tanner |
| 17/12/2011 | Crewe | 1 | 1 | Crawley Town | S Attwell |
| 26/12/2011 | Bradford | 3 | 0 | Crewe | P Tierney |
| 31/12/2011 | Bristol Rvs | 2 | 5 | Crewe | I Williamson |
| 02/01/2012 | Crewe | 0 | 1 | Morecambe | M Naylor |
| 07/01/2012 | Crewe | 3 | 2 | Plymouth | A Madley |
| 14/01/2012 | Oxford | 0 | 1 | Crewe | L Collins |
| 21/01/2012 | Crewe | 4 | 1 | Dag and Red | J Simpson |
| 28/01/2012 | Barnet | 2 | 0 | Crewe | D Sheldrake |
| 14/02/2012 | Crewe | 3 | 2 | Burton | P Gibbs |
| 18/02/2012 | Southend | 1 | 0 | Crewe | A Woolmer |
| 21/02/2012 | Crewe | 2 | 0 | Accrington | R Madley |
| 25/02/2012 | Crewe | 3 | 3 | AFC Wimbledon | D Mohareb |
| 28/02/2012 | Port Vale | 1 | 1 | Crewe | G Scott |
| 03/03/2012 | Crewe | 1 | 1 | Shrewsbury | D Webb |
| 06/03/2012 | Rotherham | 1 | 1 | Crewe | C Sarginson |
| 10/03/2012 | Gillingham | 3 | 4 | Crewe | K Stroud |
| 17/03/2012 | Crewe | 2 | 0 | Swindon | D Deadman |
| 20/03/2012 | Crewe | 1 | 0 | Bradford | D Whitestone |
| 24/03/2012 | Hereford | 0 | 1 | Crewe | J Adcock |
| 31/03/2012 | Crewe | 1 | 1 | Northampton | P Miller |
| 06/04/2012 | Crawley Town | 1 | 1 | Crewe | B Malone |
| 09/04/2012 | Crewe | 3 | 0 | Bristol Rvs | F Graham |
| 14/04/2012 | Macclesfield | 2 | 2 | Crewe | N Miller |
| 21/04/2012 | Crewe | 1 | 0 | Cheltenham | O Langford |
| 28/04/2012 | Torquay | 1 | 1 | Crewe | D Whitestone |
| 05/05/2012 | Crewe | 2 | 2 | Aldershot | G Eltringham |