Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 14/08/2010 | Wolves | 2 | 1 | Stoke | L Probert |
| 21/08/2010 | Everton | 1 | 1 | Wolves | L Mason |
| 28/08/2010 | Wolves | 1 | 1 | Newcastle | S Attwell |
| 11/09/2010 | Fulham | 2 | 1 | Wolves | P Dowd |
| 18/09/2010 | Tottenham | 3 | 1 | Wolves | M Jones |
| 26/09/2010 | Wolves | 1 | 2 | Aston Villa | M Halsey |
| 02/10/2010 | Wigan | 2 | 0 | Wolves | L Mason |
| 16/10/2010 | Wolves | 1 | 1 | West Ham | M Clattenburg |
| 23/10/2010 | Chelsea | 2 | 0 | Wolves | L Probert |
| 30/10/2010 | Wolves | 2 | 1 | Man City | M Dean |
| 06/11/2010 | Man United | 2 | 1 | Wolves | P Dowd |
| 10/11/2010 | Wolves | 0 | 2 | Arsenal | M Halsey |
| 13/11/2010 | Wolves | 2 | 3 | Bolton | P Walton |
| 20/11/2010 | Blackpool | 2 | 1 | Wolves | M Clattenburg |
| 27/11/2010 | Wolves | 3 | 2 | Sunderland | M Jones |
| 04/12/2010 | Blackburn | 3 | 0 | Wolves | H Webb |
| 12/12/2010 | Wolves | 1 | 0 | Birmingham | M Atkinson |
| 26/12/2010 | Wolves | 1 | 2 | Wigan | M Dean |
| 29/12/2010 | Liverpool | 0 | 1 | Wolves | P Walton |
| 01/01/2011 | West Ham | 2 | 0 | Wolves | L Probert |
| 05/01/2011 | Wolves | 1 | 0 | Chelsea | M Halsey |
| 15/01/2011 | Man City | 4 | 3 | Wolves | L Mason |
| 22/01/2011 | Wolves | 0 | 3 | Liverpool | M Atkinson |
| 02/02/2011 | Bolton | 1 | 0 | Wolves | P Walton |
| 05/02/2011 | Wolves | 2 | 1 | Man United | M Oliver |
| 12/02/2011 | Arsenal | 2 | 0 | Wolves | C Foy |
| 20/02/2011 | West Brom | 1 | 1 | Wolves | M Dean |
| 26/02/2011 | Wolves | 4 | 0 | Blackpool | N Swarbrick |
| 06/03/2011 | Wolves | 3 | 3 | Tottenham | M Halsey |
| 19/03/2011 | Aston Villa | 0 | 1 | Wolves | P Dowd |
| 02/04/2011 | Newcastle | 4 | 1 | Wolves | M Dean |
| 09/04/2011 | Wolves | 0 | 3 | Everton | P Dowd |
| 23/04/2011 | Wolves | 1 | 1 | Fulham | M Oliver |
| 26/04/2011 | Stoke | 3 | 0 | Wolves | L Mason |
| 01/05/2011 | Birmingham | 1 | 1 | Wolves | K Friend |
| 08/05/2011 | Wolves | 3 | 1 | West Brom | M Dean |
| 14/05/2011 | Sunderland | 1 | 3 | Wolves | M Jones |
| 22/05/2011 | Wolves | 2 | 3 | Blackburn | H Webb |