Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Shrewsbury | 3 | 1 | Bradford | S Rushton |
| 14/08/2010 | Macclesfield | 0 | 1 | Shrewsbury | M Haywood |
| 21/08/2010 | Shrewsbury | 1 | 1 | Aldershot | P Miller |
| 28/08/2010 | Stockport | 0 | 4 | Shrewsbury | P Quinn |
| 04/09/2010 | Shrewsbury | 1 | 0 | Rotherham | T Kettle |
| 11/09/2010 | Gillingham | 2 | 0 | Shrewsbury | R Madley |
| 18/09/2010 | Shrewsbury | 3 | 1 | Northampton | M Naylor |
| 25/09/2010 | Wycombe | 2 | 2 | Shrewsbury | G Hegley |
| 28/09/2010 | Port Vale | 1 | 0 | Shrewsbury | S Mathieson |
| 02/10/2010 | Shrewsbury | 1 | 1 | Torquay | C Sarginson |
| 09/10/2010 | Morecambe | 1 | 0 | Shrewsbury | D Foster |
| 16/10/2010 | Shrewsbury | 2 | 0 | Lincoln | P Gibbs |
| 23/10/2010 | Chesterfield | 4 | 3 | Shrewsbury | N Swarbrick |
| 30/10/2010 | Shrewsbury | 2 | 1 | Barnet | C Pawson |
| 02/11/2010 | Crewe | 1 | 2 | Shrewsbury | K Evans |
| 13/11/2010 | Stevenage | 1 | 1 | Shrewsbury | R East |
| 20/11/2010 | Shrewsbury | 1 | 1 | Southend | R Shoebridge |
| 23/11/2010 | Shrewsbury | 4 | 0 | Hereford | M Haywood |
| 11/12/2010 | Shrewsbury | 1 | 1 | Cheltenham | G Ward |
| 01/01/2011 | Burton | 0 | 0 | Shrewsbury | O Langford |
| 03/01/2011 | Shrewsbury | 0 | 1 | Crewe | G Horwood |
| 08/01/2011 | Shrewsbury | 1 | 3 | Morecambe | M Brown |
| 15/01/2011 | Barnet | 1 | 1 | Shrewsbury | A Bates |
| 18/01/2011 | Accrington | 1 | 3 | Shrewsbury | C Sarginson |
| 22/01/2011 | Shrewsbury | 0 | 0 | Chesterfield | S Mathieson |
| 25/01/2011 | Oxford | 3 | 1 | Shrewsbury | S Tanner |
| 28/01/2011 | Bury | 1 | 0 | Shrewsbury | R Booth |
| 01/02/2011 | Shrewsbury | 3 | 0 | Burton | M Russell |
| 05/02/2011 | Southend | 0 | 2 | Shrewsbury | G Salisbury |
| 08/02/2011 | Lincoln | 1 | 5 | Shrewsbury | J Moss |
| 12/02/2011 | Shrewsbury | 1 | 0 | Stevenage | G Sutton |
| 26/02/2011 | Shrewsbury | 0 | 0 | Gillingham | G Eltringham |
| 01/03/2011 | Shrewsbury | 0 | 3 | Bury | A Bates |
| 05/03/2011 | Northampton | 2 | 3 | Shrewsbury | T Kettle |
| 08/03/2011 | Shrewsbury | 2 | 2 | Port Vale | P Gibbs |
| 12/03/2011 | Torquay | 5 | 0 | Shrewsbury | D Sheldrake |
| 19/03/2011 | Shrewsbury | 1 | 1 | Wycombe | J Linington |
| 26/03/2011 | Bradford | 1 | 2 | Shrewsbury | P Quinn |
| 29/03/2011 | Rotherham | 1 | 3 | Shrewsbury | D Phillips |
| 02/04/2011 | Shrewsbury | 4 | 1 | Macclesfield | D Drysdale |
| 09/04/2011 | Aldershot | 3 | 0 | Shrewsbury | M Naylor |
| 16/04/2011 | Shrewsbury | 2 | 0 | Stockport | S Hooper |
| 23/04/2011 | Hereford | 0 | 2 | Shrewsbury | G Eltringham |
| 25/04/2011 | Shrewsbury | 0 | 0 | Accrington | D Coote |
| 30/04/2011 | Cheltenham | 0 | 1 | Shrewsbury | M Brown |
| 07/05/2011 | Shrewsbury | 3 | 0 | Oxford | P Tierney |