Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Sheffield Weds | 2 | 0 | Dag and Red | E Ilderton |
| 14/08/2010 | Colchester | 1 | 1 | Sheffield Weds | D Phillips |
| 21/08/2010 | Sheffield Weds | 1 | 0 | Brighton | A Woolmer |
| 28/08/2010 | Hartlepool | 0 | 5 | Sheffield Weds | N Swarbrick |
| 05/09/2010 | Brentford | 1 | 0 | Sheffield Weds | G Hegley |
| 11/09/2010 | Sheffield Weds | 0 | 1 | Carlisle | C Sarginson |
| 18/09/2010 | Plymouth | 3 | 2 | Sheffield Weds | A Penn |
| 25/09/2010 | Sheffield Weds | 0 | 1 | Southampton | G Salisbury |
| 28/09/2010 | Sheffield Weds | 0 | 0 | Oldham | D Webb |
| 02/10/2010 | Notts County | 0 | 2 | Sheffield Weds | A Taylor |
| 09/10/2010 | Sheffield Weds | 1 | 0 | Leyton Orient | G Eltringham |
| 16/10/2010 | Yeovil | 0 | 2 | Sheffield Weds | G Scott |
| 23/10/2010 | Sheffield Weds | 1 | 1 | Bournemouth | R Booth |
| 30/10/2010 | Charlton | 1 | 0 | Sheffield Weds | R East |
| 02/11/2010 | Sheffield Weds | 0 | 2 | Huddersfield | P Crossley |
| 13/11/2010 | Sheffield Weds | 2 | 0 | Rochdale | S Rushton |
| 20/11/2010 | Milton Keynes Dons | 1 | 4 | Sheffield Weds | P Tierney |
| 23/11/2010 | Sheffield Weds | 3 | 0 | Walsall | J Linington |
| 04/12/2010 | Swindon | 2 | 1 | Sheffield Weds | M Russell |
| 11/12/2010 | Sheffield Weds | 6 | 2 | Bristol Rvs | C Webster |
| 18/12/2010 | Exeter | 5 | 1 | Sheffield Weds | F Graham |
| 03/01/2011 | Huddersfield | 1 | 0 | Sheffield Weds | M Oliver |
| 15/01/2011 | Sheffield Weds | 2 | 2 | Charlton | C Boyeson |
| 22/01/2011 | Leyton Orient | 4 | 0 | Sheffield Weds | O Langford |
| 25/01/2011 | Sheffield Weds | 2 | 2 | Yeovil | T Kettle |
| 01/02/2011 | Peterboro | 5 | 3 | Sheffield Weds | G Eltringham |
| 05/02/2011 | Sheffield Weds | 2 | 2 | Milton Keynes Dons | D McDermid |
| 12/02/2011 | Rochdale | 2 | 1 | Sheffield Weds | P Walton |
| 15/02/2011 | Tranmere | 3 | 0 | Sheffield Weds | N Swarbrick |
| 22/02/2011 | Bournemouth | 0 | 0 | Sheffield Weds | G Horwood |
| 26/02/2011 | Carlisle | 0 | 1 | Sheffield Weds | D Coote |
| 05/03/2011 | Sheffield Weds | 2 | 4 | Plymouth | I Williamson |
| 08/03/2011 | Oldham | 2 | 3 | Sheffield Weds | E Ilderton |
| 12/03/2011 | Sheffield Weds | 0 | 1 | Notts County | M Brown |
| 15/03/2011 | Sheffield Weds | 1 | 4 | Peterboro | K Evans |
| 19/03/2011 | Southampton | 2 | 0 | Sheffield Weds | D Deadman |
| 26/03/2011 | Dag and Red | 1 | 1 | Sheffield Weds | S Rushton |
| 29/03/2011 | Sheffield Weds | 1 | 3 | Brentford | A Haines |
| 02/04/2011 | Sheffield Weds | 2 | 1 | Colchester | S Mathieson |
| 05/04/2011 | Sheffield Weds | 4 | 0 | Tranmere | D Whitestone |
| 09/04/2011 | Brighton | 2 | 0 | Sheffield Weds | C Boyeson |
| 16/04/2011 | Sheffield Weds | 2 | 0 | Hartlepool | G Ward |
| 23/04/2011 | Walsall | 1 | 1 | Sheffield Weds | S Hooper |
| 25/04/2011 | Sheffield Weds | 3 | 1 | Swindon | G Eltringham |
| 30/04/2011 | Bristol Rvs | 1 | 1 | Sheffield Weds | D Foster |
| 07/05/2011 | Sheffield Weds | 1 | 2 | Exeter | A D'Urso |