Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Reading | 1 | 2 | Scunthorpe | F Graham |
| 14/08/2010 | Scunthorpe | 0 | 1 | Norwich | C Sarginson |
| 21/08/2010 | QPR | 2 | 0 | Scunthorpe | G Salisbury |
| 28/08/2010 | Scunthorpe | 3 | 0 | Crystal Palace | D Whitestone |
| 11/09/2010 | Scunthorpe | 0 | 2 | Bristol City | A Haines |
| 14/09/2010 | Sheffield United | 0 | 4 | Scunthorpe | N Swarbrick |
| 18/09/2010 | Swansea | 2 | 0 | Scunthorpe | D McDermid |
| 25/09/2010 | Scunthorpe | 1 | 1 | Ipswich | M Haywood |
| 28/09/2010 | Scunthorpe | 0 | 0 | Barnsley | R Shoebridge |
| 02/10/2010 | Leicester | 3 | 1 | Scunthorpe | G Hegley |
| 16/10/2010 | Scunthorpe | 1 | 3 | Doncaster | M Oliver |
| 19/10/2010 | Preston | 2 | 3 | Scunthorpe | S Mathieson |
| 23/10/2010 | Watford | 0 | 2 | Scunthorpe | R East |
| 30/10/2010 | Scunthorpe | 1 | 4 | Leeds | R Booth |
| 06/11/2010 | Hull | 0 | 1 | Scunthorpe | A Taylor |
| 09/11/2010 | Scunthorpe | 0 | 2 | Middlesbrough | K Wright |
| 13/11/2010 | Scunthorpe | 2 | 4 | Cardiff | E Ilderton |
| 20/11/2010 | Derby | 3 | 2 | Scunthorpe | J Linington |
| 27/11/2010 | Scunthorpe | 0 | 2 | Coventry | C Pawson |
| 04/12/2010 | Millwall | 3 | 0 | Scunthorpe | R Booth |
| 28/12/2010 | Burnley | 0 | 2 | Scunthorpe | A Woolmer |
| 01/01/2011 | Doncaster | 3 | 0 | Scunthorpe | P Tierney |
| 03/01/2011 | Scunthorpe | 1 | 2 | Watford | A Haines |
| 15/01/2011 | Leeds | 4 | 0 | Scunthorpe | F Graham |
| 22/01/2011 | Scunthorpe | 0 | 0 | Burnley | G Hegley |
| 01/02/2011 | Middlesbrough | 2 | 0 | Scunthorpe | R Lewis |
| 05/02/2011 | Scunthorpe | 1 | 5 | Hull | M Haywood |
| 12/02/2011 | Cardiff | 1 | 0 | Scunthorpe | P Crossley |
| 16/02/2011 | Scunthorpe | 1 | 0 | Nott'm Forest | M Russell |
| 19/02/2011 | Scunthorpe | 0 | 0 | Derby | S Mathieson |
| 22/02/2011 | Scunthorpe | 3 | 2 | Sheffield United | D Foster |
| 26/02/2011 | Bristol City | 2 | 0 | Scunthorpe | S Hooper |
| 01/03/2011 | Portsmouth | 2 | 0 | Scunthorpe | G Salisbury |
| 05/03/2011 | Scunthorpe | 1 | 0 | Swansea | K Hill |
| 08/03/2011 | Barnsley | 2 | 1 | Scunthorpe | K Wright |
| 12/03/2011 | Scunthorpe | 0 | 3 | Leicester | R Shoebridge |
| 15/03/2011 | Scunthorpe | 0 | 3 | Preston | N Miller |
| 19/03/2011 | Ipswich | 2 | 0 | Scunthorpe | D Webb |
| 02/04/2011 | Norwich | 6 | 0 | Scunthorpe | O Langford |
| 09/04/2011 | Scunthorpe | 4 | 1 | QPR | E Ilderton |
| 12/04/2011 | Scunthorpe | 0 | 2 | Reading | A Woolmer |
| 16/04/2011 | Crystal Palace | 1 | 2 | Scunthorpe | K Stroud |
| 22/04/2011 | Coventry | 1 | 1 | Scunthorpe | A Bates |
| 25/04/2011 | Scunthorpe | 1 | 2 | Millwall | J Moss |
| 30/04/2011 | Nott'm Forest | 5 | 1 | Scunthorpe | D Whitestone |
| 07/05/2011 | Scunthorpe | 1 | 1 | Portsmouth | M Atkinson |