Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Reading | 1 | 2 | Scunthorpe | F Graham |
| 14/08/2010 | Portsmouth | 1 | 1 | Reading | M Russell |
| 21/08/2010 | Reading | 1 | 1 | Nott'm Forest | L Probert |
| 28/08/2010 | Leicester | 1 | 2 | Reading | C Webster |
| 11/09/2010 | Reading | 3 | 0 | Crystal Palace | K Hill |
| 14/09/2010 | Millwall | 0 | 0 | Reading | D Phillips |
| 18/09/2010 | Middlesbrough | 3 | 1 | Reading | G Salisbury |
| 25/09/2010 | Reading | 3 | 0 | Barnsley | P Miller |
| 28/09/2010 | Reading | 1 | 0 | Ipswich | P Crossley |
| 02/10/2010 | Preston | 1 | 1 | Reading | J Waugh |
| 16/10/2010 | Reading | 0 | 1 | Swansea | O Langford |
| 19/10/2010 | Bristol City | 1 | 0 | Reading | C Sarginson |
| 23/10/2010 | Burnley | 0 | 4 | Reading | N Miller |
| 30/10/2010 | Reading | 4 | 3 | Doncaster | G Hegley |
| 06/11/2010 | QPR | 3 | 1 | Reading | S Tanner |
| 10/11/2010 | Reading | 1 | 1 | Cardiff | A D'Urso |
| 13/11/2010 | Reading | 3 | 3 | Norwich | M Oliver |
| 20/11/2010 | Watford | 1 | 1 | Reading | S Hooper |
| 27/11/2010 | Reading | 0 | 0 | Leeds | F Graham |
| 11/12/2010 | Reading | 0 | 0 | Coventry | P Tierney |
| 18/12/2010 | Derby | 1 | 2 | Reading | D Deadman |
| 26/12/2010 | Reading | 4 | 1 | Bristol City | K Friend |
| 28/12/2010 | Hull | 1 | 1 | Reading | D Foster |
| 01/01/2011 | Swansea | 1 | 0 | Reading | S Hooper |
| 03/01/2011 | Reading | 2 | 1 | Burnley | G Scott |
| 15/01/2011 | Doncaster | 0 | 3 | Reading | E Ilderton |
| 22/01/2011 | Reading | 1 | 1 | Hull | J Linington |
| 01/02/2011 | Cardiff | 2 | 2 | Reading | G Ward |
| 04/02/2011 | Reading | 0 | 1 | QPR | R Booth |
| 12/02/2011 | Norwich | 2 | 1 | Reading | S Mathieson |
| 15/02/2011 | Sheffield United | 1 | 1 | Reading | T Kettle |
| 19/02/2011 | Reading | 1 | 1 | Watford | P Walton |
| 22/02/2011 | Reading | 2 | 1 | Millwall | D Whitestone |
| 26/02/2011 | Crystal Palace | 3 | 3 | Reading | A Bates |
| 05/03/2011 | Reading | 5 | 2 | Middlesbrough | N Swarbrick |
| 08/03/2011 | Ipswich | 1 | 3 | Reading | D McDermid |
| 19/03/2011 | Barnsley | 0 | 1 | Reading | S Tanner |
| 02/04/2011 | Reading | 2 | 0 | Portsmouth | K Friend |
| 05/04/2011 | Reading | 2 | 1 | Preston | M Haywood |
| 09/04/2011 | Nott'm Forest | 3 | 4 | Reading | C Pawson |
| 12/04/2011 | Scunthorpe | 0 | 2 | Reading | A Woolmer |
| 16/04/2011 | Reading | 3 | 1 | Leicester | G Salisbury |
| 22/04/2011 | Leeds | 0 | 0 | Reading | E Ilderton |
| 25/04/2011 | Reading | 2 | 3 | Sheffield United | K Wright |
| 30/04/2011 | Coventry | 0 | 0 | Reading | J Linington |
| 07/05/2011 | Reading | 2 | 1 | Derby | P Miller |