Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Preston | 0 | 2 | Doncaster | S Tanner |
| 14/08/2010 | Swansea | 4 | 0 | Preston | S Rushton |
| 21/08/2010 | Preston | 1 | 0 | Portsmouth | D Webb |
| 28/08/2010 | Sheffield United | 1 | 0 | Preston | I Williamson |
| 11/09/2010 | Burnley | 4 | 3 | Preston | K Friend |
| 14/09/2010 | Preston | 1 | 2 | Nott'm Forest | R Shoebridge |
| 18/09/2010 | Preston | 0 | 1 | Norwich | C Webster |
| 25/09/2010 | Coventry | 1 | 2 | Preston | C Boyeson |
| 28/09/2010 | Leeds | 4 | 6 | Preston | N Miller |
| 02/10/2010 | Preston | 1 | 1 | Reading | J Waugh |
| 16/10/2010 | Derby | 3 | 0 | Preston | A D'Urso |
| 19/10/2010 | Preston | 2 | 3 | Scunthorpe | S Mathieson |
| 23/10/2010 | Preston | 4 | 3 | Crystal Palace | G Eltringham |
| 30/10/2010 | Leicester | 1 | 0 | Preston | G Ward |
| 06/11/2010 | Bristol City | 1 | 1 | Preston | D Whitestone |
| 09/11/2010 | Preston | 1 | 2 | Barnsley | O Langford |
| 12/11/2010 | Preston | 0 | 2 | Hull | T Kettle |
| 20/11/2010 | QPR | 3 | 1 | Preston | D Phillips |
| 27/11/2010 | Preston | 0 | 0 | Millwall | K Wright |
| 04/12/2010 | Cardiff | 1 | 1 | Preston | D Deadman |
| 11/12/2010 | Preston | 1 | 0 | Ipswich | E Ilderton |
| 28/12/2010 | Preston | 1 | 3 | Middlesbrough | C Pawson |
| 01/01/2011 | Preston | 1 | 2 | Derby | R Madley |
| 03/01/2011 | Crystal Palace | 1 | 0 | Preston | K Hill |
| 15/01/2011 | Preston | 1 | 1 | Leicester | D Coote |
| 22/01/2011 | Middlesbrough | 1 | 1 | Preston | M Russell |
| 01/02/2011 | Barnsley | 2 | 0 | Preston | R Booth |
| 05/02/2011 | Preston | 0 | 4 | Bristol City | A Bates |
| 12/02/2011 | Hull | 1 | 0 | Preston | E Ilderton |
| 15/02/2011 | Watford | 2 | 2 | Preston | K Friend |
| 19/02/2011 | Preston | 1 | 1 | QPR | A Haines |
| 22/02/2011 | Nott'm Forest | 2 | 2 | Preston | D Deadman |
| 26/02/2011 | Preston | 1 | 2 | Burnley | H Webb |
| 05/03/2011 | Norwich | 1 | 1 | Preston | C Pawson |
| 08/03/2011 | Preston | 1 | 2 | Leeds | R Shoebridge |
| 15/03/2011 | Scunthorpe | 0 | 3 | Preston | N Miller |
| 19/03/2011 | Preston | 2 | 1 | Coventry | G Hegley |
| 02/04/2011 | Preston | 2 | 1 | Swansea | D Foster |
| 05/04/2011 | Reading | 2 | 1 | Preston | M Haywood |
| 09/04/2011 | Portsmouth | 1 | 1 | Preston | D McDermid |
| 12/04/2011 | Doncaster | 1 | 1 | Preston | S Mathieson |
| 16/04/2011 | Preston | 3 | 1 | Sheffield United | S Tanner |
| 23/04/2011 | Millwall | 4 | 0 | Preston | C Boyeson |
| 25/04/2011 | Preston | 0 | 1 | Cardiff | P Gibbs |
| 30/04/2011 | Ipswich | 2 | 1 | Preston | K Wright |
| 07/05/2011 | Preston | 3 | 1 | Watford | F Graham |