Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Coventry | 2 | 0 | Portsmouth | A D'Urso |
| 14/08/2010 | Portsmouth | 1 | 1 | Reading | M Russell |
| 21/08/2010 | Preston | 1 | 0 | Portsmouth | D Webb |
| 28/08/2010 | Portsmouth | 0 | 2 | Cardiff | A Penn |
| 11/09/2010 | Portsmouth | 0 | 0 | Ipswich | S Tanner |
| 14/09/2010 | Crystal Palace | 4 | 1 | Portsmouth | P Walton |
| 18/09/2010 | Sheffield United | 1 | 0 | Portsmouth | G Hegley |
| 24/09/2010 | Portsmouth | 6 | 1 | Leicester | K Hill |
| 28/09/2010 | Portsmouth | 3 | 1 | Bristol City | G Horwood |
| 02/10/2010 | Middlesbrough | 2 | 2 | Portsmouth | R Shoebridge |
| 16/10/2010 | Portsmouth | 3 | 2 | Watford | D McDermid |
| 19/10/2010 | Millwall | 0 | 1 | Portsmouth | A Woolmer |
| 23/10/2010 | Hull | 1 | 2 | Portsmouth | D Deadman |
| 30/10/2010 | Portsmouth | 2 | 1 | Nott'm Forest | M Haywood |
| 06/11/2010 | Derby | 2 | 0 | Portsmouth | C Webster |
| 09/11/2010 | Portsmouth | 1 | 1 | QPR | G Ward |
| 13/11/2010 | Portsmouth | 2 | 3 | Doncaster | G Scott |
| 20/11/2010 | Barnsley | 1 | 0 | Portsmouth | D Foster |
| 26/11/2010 | Swansea | 1 | 2 | Portsmouth | S Tanner |
| 11/12/2010 | Norwich | 0 | 2 | Portsmouth | S Hooper |
| 26/12/2010 | Portsmouth | 1 | 1 | Millwall | D Phillips |
| 28/12/2010 | Leeds | 3 | 3 | Portsmouth | D Webb |
| 01/01/2011 | Watford | 3 | 0 | Portsmouth | A D'Urso |
| 03/01/2011 | Portsmouth | 2 | 3 | Hull | R Shoebridge |
| 15/01/2011 | Nott'm Forest | 2 | 1 | Portsmouth | K Friend |
| 22/01/2011 | Portsmouth | 2 | 2 | Leeds | A Taylor |
| 25/01/2011 | Portsmouth | 1 | 2 | Burnley | S Attwell |
| 01/02/2011 | QPR | 2 | 0 | Portsmouth | G Hegley |
| 05/02/2011 | Portsmouth | 1 | 1 | Derby | N Swarbrick |
| 12/02/2011 | Doncaster | 0 | 2 | Portsmouth | A Haines |
| 19/02/2011 | Portsmouth | 1 | 0 | Barnsley | R East |
| 22/02/2011 | Portsmouth | 1 | 0 | Crystal Palace | B Malone |
| 26/02/2011 | Ipswich | 0 | 2 | Portsmouth | S Mathieson |
| 01/03/2011 | Portsmouth | 2 | 0 | Scunthorpe | G Salisbury |
| 05/03/2011 | Portsmouth | 1 | 0 | Sheffield United | R Booth |
| 08/03/2011 | Bristol City | 2 | 1 | Portsmouth | J Moss |
| 12/03/2011 | Portsmouth | 0 | 0 | Middlesbrough | P Crossley |
| 19/03/2011 | Leicester | 0 | 1 | Portsmouth | P Tierney |
| 02/04/2011 | Reading | 2 | 0 | Portsmouth | K Friend |
| 09/04/2011 | Portsmouth | 1 | 1 | Preston | D McDermid |
| 12/04/2011 | Portsmouth | 0 | 3 | Coventry | D Whitestone |
| 16/04/2011 | Cardiff | 3 | 0 | Portsmouth | K Wright |
| 23/04/2011 | Portsmouth | 0 | 0 | Swansea | D Deadman |
| 25/04/2011 | Burnley | 1 | 1 | Portsmouth | C Boyeson |
| 02/05/2011 | Portsmouth | 0 | 1 | Norwich | A D'Urso |
| 07/05/2011 | Scunthorpe | 1 | 1 | Portsmouth | M Atkinson |